Host proviral and antiviral factors for SARS-CoV-2

Throughout the viral life cycle, interplays between cellular host factors and virus determine the infectious capacity of the virus. The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a great threat to human life and health...

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Detalles Bibliográficos
Autores principales: Lv, Lu, Zhang, Leiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Review Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435179/
https://www.ncbi.nlm.nih.gov/pubmed/34510331
http://dx.doi.org/10.1007/s11262-021-01869-2
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author Lv, Lu
Zhang, Leiliang
author_facet Lv, Lu
Zhang, Leiliang
author_sort Lv, Lu
collection PubMed
description Throughout the viral life cycle, interplays between cellular host factors and virus determine the infectious capacity of the virus. The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a great threat to human life and health. Extensive studies identified a number of host proviral and antiviral factors for SARS-CoV-2. In this review, we summarize the current understanding of the interplay between SARS-CoV-2 and cellular factors during virus entry and replication. Our review will highlight the future direction of study on the infection and pathogenesis of SARS-CoV-2, as well as novel therapeutic strategies and effective antiviral targets for COVID-19.
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spelling pubmed-84351792021-09-13 Host proviral and antiviral factors for SARS-CoV-2 Lv, Lu Zhang, Leiliang Virus Genes Review Paper Throughout the viral life cycle, interplays between cellular host factors and virus determine the infectious capacity of the virus. The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a great threat to human life and health. Extensive studies identified a number of host proviral and antiviral factors for SARS-CoV-2. In this review, we summarize the current understanding of the interplay between SARS-CoV-2 and cellular factors during virus entry and replication. Our review will highlight the future direction of study on the infection and pathogenesis of SARS-CoV-2, as well as novel therapeutic strategies and effective antiviral targets for COVID-19. Springer US 2021-09-11 2021 /pmc/articles/PMC8435179/ /pubmed/34510331 http://dx.doi.org/10.1007/s11262-021-01869-2 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Paper
Lv, Lu
Zhang, Leiliang
Host proviral and antiviral factors for SARS-CoV-2
title Host proviral and antiviral factors for SARS-CoV-2
title_full Host proviral and antiviral factors for SARS-CoV-2
title_fullStr Host proviral and antiviral factors for SARS-CoV-2
title_full_unstemmed Host proviral and antiviral factors for SARS-CoV-2
title_short Host proviral and antiviral factors for SARS-CoV-2
title_sort host proviral and antiviral factors for sars-cov-2
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435179/
https://www.ncbi.nlm.nih.gov/pubmed/34510331
http://dx.doi.org/10.1007/s11262-021-01869-2
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