A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts

Mutations in the PKD2 gene cause autosomal-dominant polycystic kidney disease but the physiological role of polycystin-2, the protein product of PKD2, remains elusive. Polycystin-2 belongs to the transient receptor potential (TRP) family of non-selective cation channels. To test the hypothesis that...

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Detalles Bibliográficos
Autores principales: Grosch, Melanie, Brunner, Katrin, Ilyaskin, Alexandr V., Schober, Michael, Staudner, Tobias, Schmied, Denise, Stumpp, Tina, Schmidt, Kerstin N., Madej, M. Gregor, Pessoa, Thaissa D., Othmen, Helga, Kubitza, Marion, Osten, Larissa, de Vries, Uwe, Mair, Magdalena M., Somlo, Stefan, Moser, Markus, Kunzelmann, Karl, Ziegler, Christine, Haerteis, Silke, Korbmacher, Christoph, Witzgall, Ralph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435292/
https://www.ncbi.nlm.nih.gov/pubmed/34345895
http://dx.doi.org/10.1242/jcs.259013

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