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Coronavirus disease 2019 outcomes in heart transplant recipients: a single-center case series

BACKGROUND: With the rapidly expanding pandemic of severe acute respiratory syndrome coronavirus-2, a chronic immunosuppressed state in solid organ transplant recipients is a concern. We reported coronavirus disease 2019 in heart transplant recipients and described the patients’ course from diagnosi...

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Autores principales: Naghashzadeh, Farah, Shafaghi, Shadi, Sharif-Kashani, Babak, Tabarsi, Payam, Saliminejad, Leila, Noorali, Sima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435348/
https://www.ncbi.nlm.nih.gov/pubmed/34511111
http://dx.doi.org/10.1186/s13256-021-03028-5
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author Naghashzadeh, Farah
Shafaghi, Shadi
Sharif-Kashani, Babak
Tabarsi, Payam
Saliminejad, Leila
Noorali, Sima
author_facet Naghashzadeh, Farah
Shafaghi, Shadi
Sharif-Kashani, Babak
Tabarsi, Payam
Saliminejad, Leila
Noorali, Sima
author_sort Naghashzadeh, Farah
collection PubMed
description BACKGROUND: With the rapidly expanding pandemic of severe acute respiratory syndrome coronavirus-2, a chronic immunosuppressed state in solid organ transplant recipients is a concern. We reported coronavirus disease 2019 in heart transplant recipients and described the patients’ course from diagnosis to either hospital admission or improvement in symptoms. CASE PRESENTATION: This study retrospectively identified 13 white (Iranian) heart transplant patients with coronavirus disease 2019 between December 2019 and October 2020. The mean age of patients was 43.7 years (19–65 years); seven (70%) were men. Laboratory and treatment data were collected for those admitted or managed as outpatients. Outcomes were also recorded for all patients. This report demonstrates a range of symptoms, clinical severity, and disease course in heart transplant recipients with coronavirus disease 2019, including ten hospitalized patients and three patients, managed entirely in the outpatient setting. One patient passed away, and none of them experienced an episode of clinically overt rejection. CONCLUSIONS: We would like to emphasize the importance of being alert in these patients to consider testing in a broad range of clinical presentations and gathering more data for better management.
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spelling pubmed-84353482021-09-13 Coronavirus disease 2019 outcomes in heart transplant recipients: a single-center case series Naghashzadeh, Farah Shafaghi, Shadi Sharif-Kashani, Babak Tabarsi, Payam Saliminejad, Leila Noorali, Sima J Med Case Rep Case Report BACKGROUND: With the rapidly expanding pandemic of severe acute respiratory syndrome coronavirus-2, a chronic immunosuppressed state in solid organ transplant recipients is a concern. We reported coronavirus disease 2019 in heart transplant recipients and described the patients’ course from diagnosis to either hospital admission or improvement in symptoms. CASE PRESENTATION: This study retrospectively identified 13 white (Iranian) heart transplant patients with coronavirus disease 2019 between December 2019 and October 2020. The mean age of patients was 43.7 years (19–65 years); seven (70%) were men. Laboratory and treatment data were collected for those admitted or managed as outpatients. Outcomes were also recorded for all patients. This report demonstrates a range of symptoms, clinical severity, and disease course in heart transplant recipients with coronavirus disease 2019, including ten hospitalized patients and three patients, managed entirely in the outpatient setting. One patient passed away, and none of them experienced an episode of clinically overt rejection. CONCLUSIONS: We would like to emphasize the importance of being alert in these patients to consider testing in a broad range of clinical presentations and gathering more data for better management. BioMed Central 2021-09-13 /pmc/articles/PMC8435348/ /pubmed/34511111 http://dx.doi.org/10.1186/s13256-021-03028-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Naghashzadeh, Farah
Shafaghi, Shadi
Sharif-Kashani, Babak
Tabarsi, Payam
Saliminejad, Leila
Noorali, Sima
Coronavirus disease 2019 outcomes in heart transplant recipients: a single-center case series
title Coronavirus disease 2019 outcomes in heart transplant recipients: a single-center case series
title_full Coronavirus disease 2019 outcomes in heart transplant recipients: a single-center case series
title_fullStr Coronavirus disease 2019 outcomes in heart transplant recipients: a single-center case series
title_full_unstemmed Coronavirus disease 2019 outcomes in heart transplant recipients: a single-center case series
title_short Coronavirus disease 2019 outcomes in heart transplant recipients: a single-center case series
title_sort coronavirus disease 2019 outcomes in heart transplant recipients: a single-center case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435348/
https://www.ncbi.nlm.nih.gov/pubmed/34511111
http://dx.doi.org/10.1186/s13256-021-03028-5
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