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Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis
BACKGROUND: Patients with sepsis are at risk for developing sepsis-induced cardiomyopathy (SIC). Previous studies offer inconsistent results regarding the association of SIC and mortality. This study sought to assess whether SIC is linked to mortality in patients with sepsis and to evaluate predicto...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Critical Care Medicine
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435447/ https://www.ncbi.nlm.nih.gov/pubmed/34311515 http://dx.doi.org/10.4266/acc.2021.00234 |
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author | Hanumanthu, Balaram Krishna J Nair, Anika Sasidharan Katamreddy, Adarsh Gilbert, Jason S You, Jee Young Offor, Obiageli Lynda Kushwaha, Ankit Krishnan, Ankita Napolitano, Marzio Palaidimos, Leonidas Morante, Joaquin Tekwani, Seema S. Mehta, Suchita Gupta, Aanchal Goraya, Harmeen Sun, Mengyang Faillace, Robert T. Gulani, Perminder |
author_facet | Hanumanthu, Balaram Krishna J Nair, Anika Sasidharan Katamreddy, Adarsh Gilbert, Jason S You, Jee Young Offor, Obiageli Lynda Kushwaha, Ankit Krishnan, Ankita Napolitano, Marzio Palaidimos, Leonidas Morante, Joaquin Tekwani, Seema S. Mehta, Suchita Gupta, Aanchal Goraya, Harmeen Sun, Mengyang Faillace, Robert T. Gulani, Perminder |
author_sort | Hanumanthu, Balaram Krishna J |
collection | PubMed |
description | BACKGROUND: Patients with sepsis are at risk for developing sepsis-induced cardiomyopathy (SIC). Previous studies offer inconsistent results regarding the association of SIC and mortality. This study sought to assess whether SIC is linked to mortality in patients with sepsis and to evaluate predictors of the development of SIC. METHODS: In this retrospective study, patients admitted to the medical intensive care unit with a diagnosis of sepsis in the absence of acute coronary syndrome were included. SIC was identified using transthoracic echo and was defined by a new onset decline in left ventricular ejection fraction (LVEF) ≤50%, or ≥10% decline in LVEF compared to baseline in patients with a history of heart failure with reduced ejection fraction. Multivariable logistic regression analysis was performed using the R software program. RESULTS: Of the 359 patients in the final analysis, 19 (5.3%) had SIC. Eight (42.1%) of the 19 patients in the SIC group and 60 (17.6%) of the 340 patients in the non-SIC group died during hospitalization. SIC was associated with an increased risk for all-cause in-hospital mortality (odds ratio [OR], 4.46; 95% confidence interval [CI], 1.15–18.69; P=0.03). Independent predictors for the development of SIC were albumin level (OR, 0.47; 95% CI, 0.23–0.93; P=0.03) and culture positivity (OR, 8.47; 95% CI, 2.24–55.61; P=0.006). Concomitant right ventricular hypokinesis was noted in 13 (68.4%) of the 19 SIC patients. CONCLUSIONS: SIC was associated with an increased risk for all-cause in-hospital mortality. Low albumin level and culture positivity were independent predictors of SIC. |
format | Online Article Text |
id | pubmed-8435447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean Society of Critical Care Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-84354472021-09-20 Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis Hanumanthu, Balaram Krishna J Nair, Anika Sasidharan Katamreddy, Adarsh Gilbert, Jason S You, Jee Young Offor, Obiageli Lynda Kushwaha, Ankit Krishnan, Ankita Napolitano, Marzio Palaidimos, Leonidas Morante, Joaquin Tekwani, Seema S. Mehta, Suchita Gupta, Aanchal Goraya, Harmeen Sun, Mengyang Faillace, Robert T. Gulani, Perminder Acute Crit Care Original Article BACKGROUND: Patients with sepsis are at risk for developing sepsis-induced cardiomyopathy (SIC). Previous studies offer inconsistent results regarding the association of SIC and mortality. This study sought to assess whether SIC is linked to mortality in patients with sepsis and to evaluate predictors of the development of SIC. METHODS: In this retrospective study, patients admitted to the medical intensive care unit with a diagnosis of sepsis in the absence of acute coronary syndrome were included. SIC was identified using transthoracic echo and was defined by a new onset decline in left ventricular ejection fraction (LVEF) ≤50%, or ≥10% decline in LVEF compared to baseline in patients with a history of heart failure with reduced ejection fraction. Multivariable logistic regression analysis was performed using the R software program. RESULTS: Of the 359 patients in the final analysis, 19 (5.3%) had SIC. Eight (42.1%) of the 19 patients in the SIC group and 60 (17.6%) of the 340 patients in the non-SIC group died during hospitalization. SIC was associated with an increased risk for all-cause in-hospital mortality (odds ratio [OR], 4.46; 95% confidence interval [CI], 1.15–18.69; P=0.03). Independent predictors for the development of SIC were albumin level (OR, 0.47; 95% CI, 0.23–0.93; P=0.03) and culture positivity (OR, 8.47; 95% CI, 2.24–55.61; P=0.006). Concomitant right ventricular hypokinesis was noted in 13 (68.4%) of the 19 SIC patients. CONCLUSIONS: SIC was associated with an increased risk for all-cause in-hospital mortality. Low albumin level and culture positivity were independent predictors of SIC. Korean Society of Critical Care Medicine 2021-08 2021-07-26 /pmc/articles/PMC8435447/ /pubmed/34311515 http://dx.doi.org/10.4266/acc.2021.00234 Text en Copyright © 2021 The Korean Society of Critical Care Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Hanumanthu, Balaram Krishna J Nair, Anika Sasidharan Katamreddy, Adarsh Gilbert, Jason S You, Jee Young Offor, Obiageli Lynda Kushwaha, Ankit Krishnan, Ankita Napolitano, Marzio Palaidimos, Leonidas Morante, Joaquin Tekwani, Seema S. Mehta, Suchita Gupta, Aanchal Goraya, Harmeen Sun, Mengyang Faillace, Robert T. Gulani, Perminder Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis |
title | Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis |
title_full | Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis |
title_fullStr | Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis |
title_full_unstemmed | Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis |
title_short | Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis |
title_sort | sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435447/ https://www.ncbi.nlm.nih.gov/pubmed/34311515 http://dx.doi.org/10.4266/acc.2021.00234 |
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