Cargando…

Closed-Loop Identification of Baroreflex Properties in the Frequency Domain

The arterial baroreflex system plays a key role in maintaining the homeostasis of arterial pressure (AP). Changes in AP affect autonomic nervous activities through the baroreflex neural arc, whereas changes in the autonomic nervous activities, in turn, alter AP through the baroreflex peripheral arc....

Descripción completa

Detalles Bibliográficos
Autores principales: Kawada, Toru, Saku, Keita, Miyamoto, Tadayoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435638/
https://www.ncbi.nlm.nih.gov/pubmed/34526878
http://dx.doi.org/10.3389/fnins.2021.694512
_version_ 1783751837614080000
author Kawada, Toru
Saku, Keita
Miyamoto, Tadayoshi
author_facet Kawada, Toru
Saku, Keita
Miyamoto, Tadayoshi
author_sort Kawada, Toru
collection PubMed
description The arterial baroreflex system plays a key role in maintaining the homeostasis of arterial pressure (AP). Changes in AP affect autonomic nervous activities through the baroreflex neural arc, whereas changes in the autonomic nervous activities, in turn, alter AP through the baroreflex peripheral arc. This closed-loop negative feedback operation makes it difficult to identify open-loop dynamic characteristics of the neural and peripheral arcs. Regarding sympathetic AP controls, we examined the applicability of a nonparametric frequency-domain closed-loop identification method to the carotid sinus baroreflex system in anesthetized rabbits. This article compares the results of an open-loop analysis applied to open-loop data, an open-loop analysis erroneously applied to closed-loop data, and a closed-loop analysis applied to closed-loop data. To facilitate the understanding of the analytical method, sample data files and sample analytical codes were provided. In the closed-loop identification, properties of the unknown central noise that modulated the sympathetic nerve activity and the unknown peripheral noise that fluctuated AP affected the accuracy of the estimation results. A priori knowledge about the open-loop dynamic characteristics of the arterial baroreflex system may be used to advance the assessment of baroreflex function under closed-loop conditions in the future.
format Online
Article
Text
id pubmed-8435638
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-84356382021-09-14 Closed-Loop Identification of Baroreflex Properties in the Frequency Domain Kawada, Toru Saku, Keita Miyamoto, Tadayoshi Front Neurosci Neuroscience The arterial baroreflex system plays a key role in maintaining the homeostasis of arterial pressure (AP). Changes in AP affect autonomic nervous activities through the baroreflex neural arc, whereas changes in the autonomic nervous activities, in turn, alter AP through the baroreflex peripheral arc. This closed-loop negative feedback operation makes it difficult to identify open-loop dynamic characteristics of the neural and peripheral arcs. Regarding sympathetic AP controls, we examined the applicability of a nonparametric frequency-domain closed-loop identification method to the carotid sinus baroreflex system in anesthetized rabbits. This article compares the results of an open-loop analysis applied to open-loop data, an open-loop analysis erroneously applied to closed-loop data, and a closed-loop analysis applied to closed-loop data. To facilitate the understanding of the analytical method, sample data files and sample analytical codes were provided. In the closed-loop identification, properties of the unknown central noise that modulated the sympathetic nerve activity and the unknown peripheral noise that fluctuated AP affected the accuracy of the estimation results. A priori knowledge about the open-loop dynamic characteristics of the arterial baroreflex system may be used to advance the assessment of baroreflex function under closed-loop conditions in the future. Frontiers Media S.A. 2021-08-30 /pmc/articles/PMC8435638/ /pubmed/34526878 http://dx.doi.org/10.3389/fnins.2021.694512 Text en Copyright © 2021 Kawada, Saku and Miyamoto. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Kawada, Toru
Saku, Keita
Miyamoto, Tadayoshi
Closed-Loop Identification of Baroreflex Properties in the Frequency Domain
title Closed-Loop Identification of Baroreflex Properties in the Frequency Domain
title_full Closed-Loop Identification of Baroreflex Properties in the Frequency Domain
title_fullStr Closed-Loop Identification of Baroreflex Properties in the Frequency Domain
title_full_unstemmed Closed-Loop Identification of Baroreflex Properties in the Frequency Domain
title_short Closed-Loop Identification of Baroreflex Properties in the Frequency Domain
title_sort closed-loop identification of baroreflex properties in the frequency domain
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435638/
https://www.ncbi.nlm.nih.gov/pubmed/34526878
http://dx.doi.org/10.3389/fnins.2021.694512
work_keys_str_mv AT kawadatoru closedloopidentificationofbaroreflexpropertiesinthefrequencydomain
AT sakukeita closedloopidentificationofbaroreflexpropertiesinthefrequencydomain
AT miyamototadayoshi closedloopidentificationofbaroreflexpropertiesinthefrequencydomain