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Cancer-Associated Fibroblasts Facilitate Squamous Cell Carcinoma Lung Metastasis in Mice by Providing TGFβ-Mediated Cancer Stem Cell Niche

Cancer-associated fibroblasts (CAFs) have been shown to enhance squamous cell carcinoma (SCC) growth, but it is unclear whether they promote SCC lung metastasis. We generated CAFs from K15.KrasG12D.Smad4(–/–) mouse SCCs. RNA expression analyses demonstrated that CAFs had enriched transforming growth...

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Detalles Bibliográficos
Autores principales:	Shi, Xueke, Luo, Jingjing, Weigel, Kelsey J., Hall, Spencer C., Du, Danfeng, Wu, Fanglong, Rudolph, Michael C., Zhou, Hongmei, Young, Christian D., Wang, Xiao-Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435687/ https://www.ncbi.nlm.nih.gov/pubmed/34527666 http://dx.doi.org/10.3389/fcell.2021.668164

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