Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q

Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial oxidative stress and a range of pathologies. What drives CoQ deficiency in ma...

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Detalles Bibliográficos
Autores principales: Ayer, Anita, Fazakerley, Daniel J., Suarna, Cacang, Maghzal, Ghassan J., Sheipouri, Diba, Lee, Kevin J., Bradley, Michelle C., Fernández-del-Rio, Lucía, Tumanov, Sergey, Kong, Stephanie MY., van der Veen, Jelske N., Yang, Andrian, Ho, Joshua W.K., Clarke, Steven G., James, David E., Dawes, Ian W., Vance, Dennis E., Clarke, Catherine F., Jacobs, René L., Stocker, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435697/
https://www.ncbi.nlm.nih.gov/pubmed/34521065
http://dx.doi.org/10.1016/j.redox.2021.102127

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