SPOP promotes CDCA5 degradation to regulate prostate cancer progression via the AKT pathway

The E3 ubiquitin ligase adaptor Speckle-type POZ protein (SPOP) plays an important tumour suppressor role in prostate cancers (PCa), with mutation rate up to 15%. However, how SPOP mutations regulate prostate tumorigenesis remains elusive. Here, we report the identification of cell division cycle as...

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Detalles Bibliográficos
Autores principales: Luo, Zhenzhen, Wang, Jing, Zhu, Yue, Sun, Xiao, He, Chenchen, Cai, Mengjiao, Ma, Jinlu, Wang, Yi, Han, Suxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435818/
https://www.ncbi.nlm.nih.gov/pubmed/34509929
http://dx.doi.org/10.1016/j.neo.2021.08.002

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