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Epidemiological Profile of Meningitis following Pentavalent Vaccination in Iran: Impact of Vaccine Introduction
Ensuring the effectiveness of the Haemophilus influenza type b (DTwP-Hib-HepB) vaccine in reducing meningitis is an essential approach in evaluating the effectiveness of the vaccine. The study aimed to address the epidemiology of meningitis following pentavalent vaccination in Iran. Data on meningit...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Atlantis Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435870/ https://www.ncbi.nlm.nih.gov/pubmed/33876602 http://dx.doi.org/10.2991/jegh.k.210330.001 |
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author | Heidari, Saber Karami, Manoochehr Zahraei, Seyed Mohsen Sedighi, Iraj Zavareh, Fatemeh Azimian |
author_facet | Heidari, Saber Karami, Manoochehr Zahraei, Seyed Mohsen Sedighi, Iraj Zavareh, Fatemeh Azimian |
author_sort | Heidari, Saber |
collection | PubMed |
description | Ensuring the effectiveness of the Haemophilus influenza type b (DTwP-Hib-HepB) vaccine in reducing meningitis is an essential approach in evaluating the effectiveness of the vaccine. The study aimed to address the epidemiology of meningitis following pentavalent vaccination in Iran. Data on meningitis patients from 21st March 2011 to 21st July 2018 were extracted from the National Notifiable Diseases Surveillance System. This information was divided into two equal periods before the pentavalent vaccine introduction (21st March 2011 to 17th November 2014) and after the introduction (18th November 2014 to 21st July 2018). The number of patients in the study period was 53,174 cases. More than 55% of patients were under 5 years old. Males (63.34%) were more than females (36.06%). The death rate was reduced to 2.1%; also, the proportion of confirmed cases caused by H. influenzae type b was 6.7% before the pentavalent vaccine introduction. The corresponding value following vaccine introduction equals to 3.6%. The proportion of children under five has decreased from 4.4% to 1.9%. This value indicates a 46.2% decrease in the meningitis of all ages and a 57% decrease in children under five dues to H. influenzae vaccination. The results of the study indicate the effectiveness of the vaccine due to changes in meningitis caused by H. influenzae type b after vaccination compared with no vaccination. Therefore, it is advisable to continue the full immunization coverage with the pentavalent vaccine. |
format | Online Article Text |
id | pubmed-8435870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Atlantis Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-84358702021-09-29 Epidemiological Profile of Meningitis following Pentavalent Vaccination in Iran: Impact of Vaccine Introduction Heidari, Saber Karami, Manoochehr Zahraei, Seyed Mohsen Sedighi, Iraj Zavareh, Fatemeh Azimian J Epidemiol Glob Health Research Article Ensuring the effectiveness of the Haemophilus influenza type b (DTwP-Hib-HepB) vaccine in reducing meningitis is an essential approach in evaluating the effectiveness of the vaccine. The study aimed to address the epidemiology of meningitis following pentavalent vaccination in Iran. Data on meningitis patients from 21st March 2011 to 21st July 2018 were extracted from the National Notifiable Diseases Surveillance System. This information was divided into two equal periods before the pentavalent vaccine introduction (21st March 2011 to 17th November 2014) and after the introduction (18th November 2014 to 21st July 2018). The number of patients in the study period was 53,174 cases. More than 55% of patients were under 5 years old. Males (63.34%) were more than females (36.06%). The death rate was reduced to 2.1%; also, the proportion of confirmed cases caused by H. influenzae type b was 6.7% before the pentavalent vaccine introduction. The corresponding value following vaccine introduction equals to 3.6%. The proportion of children under five has decreased from 4.4% to 1.9%. This value indicates a 46.2% decrease in the meningitis of all ages and a 57% decrease in children under five dues to H. influenzae vaccination. The results of the study indicate the effectiveness of the vaccine due to changes in meningitis caused by H. influenzae type b after vaccination compared with no vaccination. Therefore, it is advisable to continue the full immunization coverage with the pentavalent vaccine. Atlantis Press 2021-09 /pmc/articles/PMC8435870/ /pubmed/33876602 http://dx.doi.org/10.2991/jegh.k.210330.001 Text en © 2021 The Authors. Published by Atlantis Press International B.V. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ). |
spellingShingle | Research Article Heidari, Saber Karami, Manoochehr Zahraei, Seyed Mohsen Sedighi, Iraj Zavareh, Fatemeh Azimian Epidemiological Profile of Meningitis following Pentavalent Vaccination in Iran: Impact of Vaccine Introduction |
title | Epidemiological Profile of Meningitis following Pentavalent Vaccination in Iran: Impact of Vaccine Introduction |
title_full | Epidemiological Profile of Meningitis following Pentavalent Vaccination in Iran: Impact of Vaccine Introduction |
title_fullStr | Epidemiological Profile of Meningitis following Pentavalent Vaccination in Iran: Impact of Vaccine Introduction |
title_full_unstemmed | Epidemiological Profile of Meningitis following Pentavalent Vaccination in Iran: Impact of Vaccine Introduction |
title_short | Epidemiological Profile of Meningitis following Pentavalent Vaccination in Iran: Impact of Vaccine Introduction |
title_sort | epidemiological profile of meningitis following pentavalent vaccination in iran: impact of vaccine introduction |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435870/ https://www.ncbi.nlm.nih.gov/pubmed/33876602 http://dx.doi.org/10.2991/jegh.k.210330.001 |
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