The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features

Disordered cholesterol metabolism is linked to neurodegeneration. In this study we investigated the profile of cholesterol metabolites found in the cerebrospinal fluid (CSF) of Parkinson’s disease (PD) patients. When adjustments were made for confounding variables of age and sex, 7α,(25R)26-dihydrox...

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Detalles Bibliográficos
Autores principales: Griffiths, William J., Abdel-Khalik, Jonas, Moore, Sarah F., Wijeyekoon, Ruwani S., Crick, Peter J., Yutuc, Eylan, Farrell, Krista, Breen, David P., Williams-Gray, Caroline H., Theofilopoulos, Spyridon, Arenas, Ernest, Trupp, Miles, Barker, Roger A., Wang, Yuqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435905/
https://www.ncbi.nlm.nih.gov/pubmed/34526889
http://dx.doi.org/10.3389/fnagi.2021.685594
Descripción
Sumario:Disordered cholesterol metabolism is linked to neurodegeneration. In this study we investigated the profile of cholesterol metabolites found in the cerebrospinal fluid (CSF) of Parkinson’s disease (PD) patients. When adjustments were made for confounding variables of age and sex, 7α,(25R)26-dihydroxycholesterol and a second oxysterol 7α,x,y-trihydroxycholest-4-en-3-one (7α,x,y-triHCO), whose exact structure is unknown, were found to be significantly elevated in PD CSF. The likely location of the additional hydroxy groups on the second oxysterol are on the sterol side-chain. We found that CSF 7α-hydroxycholesterol levels correlated positively with depression in PD patients, while two presumptively identified cholestenoic acids correlated negatively with depression.

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