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Normative reference equations of airway dynamics assessed by whole‐body plethysmography during spontaneous breathing evaluated in infants, children, and adults
Effective specific airway resistance (sR(eff)), its reciprocal the effective specific airway conductance (sG(eff)) are computed as ratios between the integral of the resistive aerodynamic work of breathing (sWOB) and the integral of the tidal flow/volume loop, the reciprocal, respectively. Unfortuna...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436055/ https://www.ncbi.nlm.nih.gov/pubmed/34514738 http://dx.doi.org/10.14814/phy2.15027 |
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author | Kraemer, Richard Smith, Hans‐Jürgen Matthys, Heinrich |
author_facet | Kraemer, Richard Smith, Hans‐Jürgen Matthys, Heinrich |
author_sort | Kraemer, Richard |
collection | PubMed |
description | Effective specific airway resistance (sR(eff)), its reciprocal the effective specific airway conductance (sG(eff)) are computed as ratios between the integral of the resistive aerodynamic work of breathing (sWOB) and the integral of the tidal flow/volume loop, the reciprocal, respectively. Unfortunately, reference equations to obtain normative values for sR(eff), sG(eff), and sWOB are not yet available. To assess reference equations for sWOB, sR(eff), and sG(eff) during tidal breathing at resting level in healthy infants, children, and adults by a multidimensional model. Retrospectively exported data were collected from databases of five Swiss lung function centers, in which plethysmography (Jaeger Würzburg, Germany) was performed for the assessment of airway dynamics, static lung volumes, and forced breathing flow‐volume loops, in a collective of 28 healthy infants, 47 children, and 273 adults. From this cohort, reference equations were computed based on anthropometric measures, lung volumes, indices of the breathing pattern, and timing of breathing. By multi‐linear modeling reference equations of sR(eff), sG(eff), and sWOB could be defined taking as independent parameters apart from anthropometric parameters, also parameters given by the ratio between the tidal volume and functional residual capacity (FRC(pleth)/V (T)), and the ratio between V (T) and inspiratory time (V (T)/T (I)). An alternative statistical approach to define reference equations of airway dynamics reveals that apart from the subject's anthropometric measurements, parameters of the magnitude of static lung volumes, the breathing pattern, and the timing of breathing are co‐variants of reference equations of airway dynamics over a large age range. |
format | Online Article Text |
id | pubmed-8436055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84360552021-09-15 Normative reference equations of airway dynamics assessed by whole‐body plethysmography during spontaneous breathing evaluated in infants, children, and adults Kraemer, Richard Smith, Hans‐Jürgen Matthys, Heinrich Physiol Rep Original Articles Effective specific airway resistance (sR(eff)), its reciprocal the effective specific airway conductance (sG(eff)) are computed as ratios between the integral of the resistive aerodynamic work of breathing (sWOB) and the integral of the tidal flow/volume loop, the reciprocal, respectively. Unfortunately, reference equations to obtain normative values for sR(eff), sG(eff), and sWOB are not yet available. To assess reference equations for sWOB, sR(eff), and sG(eff) during tidal breathing at resting level in healthy infants, children, and adults by a multidimensional model. Retrospectively exported data were collected from databases of five Swiss lung function centers, in which plethysmography (Jaeger Würzburg, Germany) was performed for the assessment of airway dynamics, static lung volumes, and forced breathing flow‐volume loops, in a collective of 28 healthy infants, 47 children, and 273 adults. From this cohort, reference equations were computed based on anthropometric measures, lung volumes, indices of the breathing pattern, and timing of breathing. By multi‐linear modeling reference equations of sR(eff), sG(eff), and sWOB could be defined taking as independent parameters apart from anthropometric parameters, also parameters given by the ratio between the tidal volume and functional residual capacity (FRC(pleth)/V (T)), and the ratio between V (T) and inspiratory time (V (T)/T (I)). An alternative statistical approach to define reference equations of airway dynamics reveals that apart from the subject's anthropometric measurements, parameters of the magnitude of static lung volumes, the breathing pattern, and the timing of breathing are co‐variants of reference equations of airway dynamics over a large age range. John Wiley and Sons Inc. 2021-09-13 /pmc/articles/PMC8436055/ /pubmed/34514738 http://dx.doi.org/10.14814/phy2.15027 Text en © 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Kraemer, Richard Smith, Hans‐Jürgen Matthys, Heinrich Normative reference equations of airway dynamics assessed by whole‐body plethysmography during spontaneous breathing evaluated in infants, children, and adults |
title | Normative reference equations of airway dynamics assessed by whole‐body plethysmography during spontaneous breathing evaluated in infants, children, and adults |
title_full | Normative reference equations of airway dynamics assessed by whole‐body plethysmography during spontaneous breathing evaluated in infants, children, and adults |
title_fullStr | Normative reference equations of airway dynamics assessed by whole‐body plethysmography during spontaneous breathing evaluated in infants, children, and adults |
title_full_unstemmed | Normative reference equations of airway dynamics assessed by whole‐body plethysmography during spontaneous breathing evaluated in infants, children, and adults |
title_short | Normative reference equations of airway dynamics assessed by whole‐body plethysmography during spontaneous breathing evaluated in infants, children, and adults |
title_sort | normative reference equations of airway dynamics assessed by whole‐body plethysmography during spontaneous breathing evaluated in infants, children, and adults |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436055/ https://www.ncbi.nlm.nih.gov/pubmed/34514738 http://dx.doi.org/10.14814/phy2.15027 |
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