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Role of “Stiff Rim” sign obtained by shear wave elastography in diagnosis and guiding therapy of breast cancer

Background: Because the halo around the tumor in shear wave elastography (SWE) is defined as the “stiff rim” sign, the diagnosis of breast lesions with the stiff rim sign is popular. However, only a few studies have described the stiff rim sign quantitatively. Objective: This study aimed to investig...

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Autores principales: Xu, Yan-jun, Gong, Hui-ling, Hu, Bin, Hu, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436109/
https://www.ncbi.nlm.nih.gov/pubmed/34522189
http://dx.doi.org/10.7150/ijms.64243
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author Xu, Yan-jun
Gong, Hui-ling
Hu, Bin
Hu, Bing
author_facet Xu, Yan-jun
Gong, Hui-ling
Hu, Bin
Hu, Bing
author_sort Xu, Yan-jun
collection PubMed
description Background: Because the halo around the tumor in shear wave elastography (SWE) is defined as the “stiff rim” sign, the diagnosis of breast lesions with the stiff rim sign is popular. However, only a few studies have described the stiff rim sign quantitatively. Objective: This study aimed to investigate the usefulness of the stiff rim sign in the diagnosis and tumor, node, metastasis stage of breast cancer. Methods: Two hundred and ten breast lesions were analyzed retrospectively. The maximum, mean, minimum Young's modulus (YM), and the YM standard deviation in the lesion, the peritumoral stiffness (shell), and the region containing lesion and shell were obtained. The suspicious SWE feature with the best diagnostic performance was chosen to downgrade or upgrade the Breast Imaging Reporting and Data System (BI-RADS) classification. The coincidence rates of SWE and B-mode ultrasound in T staging and their positive predictive value (PPV) for T staging were compared. Results: The presence of “stiff rim” sign was selected to upgrade or downgrade the BI-RADS classification because of its best performance. In pathological benign lesions, 18.9% (25 of 132) of lesions should undergo biopsy if BI-RADS combined with the stiff rim sign were referred while it was 57.6% (76 of 132) if BI-RADS alone was referred. The coincidence rate of T2 staging evaluated by SWE was significantly higher than B-mode ultrasound (about 30% increase, P < 0.001). The PPVs of SWE for T1 and T2 staging were higher than B-mode ultrasound (P < 0.05). Conclusions: BI-RADS combined with “stiff rim” sign is expected to improve the diagnostic performance of breast lesions to avoid unnecessary biopsy. The maximum diameter of the lesion measured in SWE is more accurate than B-mode ultrasound in the estimation of T staging, which is beneficial to the treatment and prognosis of breast cancer.
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spelling pubmed-84361092021-09-13 Role of “Stiff Rim” sign obtained by shear wave elastography in diagnosis and guiding therapy of breast cancer Xu, Yan-jun Gong, Hui-ling Hu, Bin Hu, Bing Int J Med Sci Research Paper Background: Because the halo around the tumor in shear wave elastography (SWE) is defined as the “stiff rim” sign, the diagnosis of breast lesions with the stiff rim sign is popular. However, only a few studies have described the stiff rim sign quantitatively. Objective: This study aimed to investigate the usefulness of the stiff rim sign in the diagnosis and tumor, node, metastasis stage of breast cancer. Methods: Two hundred and ten breast lesions were analyzed retrospectively. The maximum, mean, minimum Young's modulus (YM), and the YM standard deviation in the lesion, the peritumoral stiffness (shell), and the region containing lesion and shell were obtained. The suspicious SWE feature with the best diagnostic performance was chosen to downgrade or upgrade the Breast Imaging Reporting and Data System (BI-RADS) classification. The coincidence rates of SWE and B-mode ultrasound in T staging and their positive predictive value (PPV) for T staging were compared. Results: The presence of “stiff rim” sign was selected to upgrade or downgrade the BI-RADS classification because of its best performance. In pathological benign lesions, 18.9% (25 of 132) of lesions should undergo biopsy if BI-RADS combined with the stiff rim sign were referred while it was 57.6% (76 of 132) if BI-RADS alone was referred. The coincidence rate of T2 staging evaluated by SWE was significantly higher than B-mode ultrasound (about 30% increase, P < 0.001). The PPVs of SWE for T1 and T2 staging were higher than B-mode ultrasound (P < 0.05). Conclusions: BI-RADS combined with “stiff rim” sign is expected to improve the diagnostic performance of breast lesions to avoid unnecessary biopsy. The maximum diameter of the lesion measured in SWE is more accurate than B-mode ultrasound in the estimation of T staging, which is beneficial to the treatment and prognosis of breast cancer. Ivyspring International Publisher 2021-08-28 /pmc/articles/PMC8436109/ /pubmed/34522189 http://dx.doi.org/10.7150/ijms.64243 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Xu, Yan-jun
Gong, Hui-ling
Hu, Bin
Hu, Bing
Role of “Stiff Rim” sign obtained by shear wave elastography in diagnosis and guiding therapy of breast cancer
title Role of “Stiff Rim” sign obtained by shear wave elastography in diagnosis and guiding therapy of breast cancer
title_full Role of “Stiff Rim” sign obtained by shear wave elastography in diagnosis and guiding therapy of breast cancer
title_fullStr Role of “Stiff Rim” sign obtained by shear wave elastography in diagnosis and guiding therapy of breast cancer
title_full_unstemmed Role of “Stiff Rim” sign obtained by shear wave elastography in diagnosis and guiding therapy of breast cancer
title_short Role of “Stiff Rim” sign obtained by shear wave elastography in diagnosis and guiding therapy of breast cancer
title_sort role of “stiff rim” sign obtained by shear wave elastography in diagnosis and guiding therapy of breast cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436109/
https://www.ncbi.nlm.nih.gov/pubmed/34522189
http://dx.doi.org/10.7150/ijms.64243
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