Extracellular Matrix Enzymes and Immune Cell Biology

Remodelling of the extracellular matrix (ECM) by ECM metalloproteinases is increasingly being associated with regulation of immune cell function. ECM metalloproteinases, including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteinases (ADAMs) and ADAMs with Thombospondin-1 motifs (AD...

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Autores principales: McMahon, Meagan, Ye, Siying, Pedrina, Jess, Dlugolenski, Daniel, Stambas, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436118/
https://www.ncbi.nlm.nih.gov/pubmed/34527702
http://dx.doi.org/10.3389/fmolb.2021.703868
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author McMahon, Meagan
Ye, Siying
Pedrina, Jess
Dlugolenski, Daniel
Stambas, John
author_facet McMahon, Meagan
Ye, Siying
Pedrina, Jess
Dlugolenski, Daniel
Stambas, John
author_sort McMahon, Meagan
collection PubMed
description Remodelling of the extracellular matrix (ECM) by ECM metalloproteinases is increasingly being associated with regulation of immune cell function. ECM metalloproteinases, including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteinases (ADAMs) and ADAMs with Thombospondin-1 motifs (ADAMTS) play a vital role in pathogen defence and have been shown to influence migration of immune cells. This review provides a current summary of the role of ECM enzymes in immune cell migration and function and discusses opportunities and limitations for development of diagnostic and therapeutic strategies targeting metalloproteinase expression and activity in the context of infectious disease.
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spelling pubmed-84361182021-09-14 Extracellular Matrix Enzymes and Immune Cell Biology McMahon, Meagan Ye, Siying Pedrina, Jess Dlugolenski, Daniel Stambas, John Front Mol Biosci Molecular Biosciences Remodelling of the extracellular matrix (ECM) by ECM metalloproteinases is increasingly being associated with regulation of immune cell function. ECM metalloproteinases, including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteinases (ADAMs) and ADAMs with Thombospondin-1 motifs (ADAMTS) play a vital role in pathogen defence and have been shown to influence migration of immune cells. This review provides a current summary of the role of ECM enzymes in immune cell migration and function and discusses opportunities and limitations for development of diagnostic and therapeutic strategies targeting metalloproteinase expression and activity in the context of infectious disease. Frontiers Media S.A. 2021-08-30 /pmc/articles/PMC8436118/ /pubmed/34527702 http://dx.doi.org/10.3389/fmolb.2021.703868 Text en Copyright © 2021 McMahon, Ye, Pedrina, Dlugolenski and Stambas. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
McMahon, Meagan
Ye, Siying
Pedrina, Jess
Dlugolenski, Daniel
Stambas, John
Extracellular Matrix Enzymes and Immune Cell Biology
title Extracellular Matrix Enzymes and Immune Cell Biology
title_full Extracellular Matrix Enzymes and Immune Cell Biology
title_fullStr Extracellular Matrix Enzymes and Immune Cell Biology
title_full_unstemmed Extracellular Matrix Enzymes and Immune Cell Biology
title_short Extracellular Matrix Enzymes and Immune Cell Biology
title_sort extracellular matrix enzymes and immune cell biology
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436118/
https://www.ncbi.nlm.nih.gov/pubmed/34527702
http://dx.doi.org/10.3389/fmolb.2021.703868
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AT pedrinajess extracellularmatrixenzymesandimmunecellbiology
AT dlugolenskidaniel extracellularmatrixenzymesandimmunecellbiology
AT stambasjohn extracellularmatrixenzymesandimmunecellbiology

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