Avelumab plus axitinib therapy for renal cell carcinoma in a patient with pulmonary alveolar proteinosis: A case report

Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the abnormal accumulation of surfactant-derived substances in the lungs. To the best of our knowledge, the successful treatment of metastatic renal cell carcinoma in patients with PAP has not been reported. Here, we describe suc...

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Autores principales: Shimizu, Nobuaki, Hasumi, Masaru, Muramatsu, Kazumichi, Tsuji, Yusuke, Takaku, Youtarou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436122/
https://www.ncbi.nlm.nih.gov/pubmed/34540590
http://dx.doi.org/10.1016/j.eucr.2021.101843
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author Shimizu, Nobuaki
Hasumi, Masaru
Muramatsu, Kazumichi
Tsuji, Yusuke
Takaku, Youtarou
author_facet Shimizu, Nobuaki
Hasumi, Masaru
Muramatsu, Kazumichi
Tsuji, Yusuke
Takaku, Youtarou
author_sort Shimizu, Nobuaki
collection PubMed
description Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the abnormal accumulation of surfactant-derived substances in the lungs. To the best of our knowledge, the successful treatment of metastatic renal cell carcinoma in patients with PAP has not been reported. Here, we describe such treatment of a patient via avelumab plus axitinib therapy. After four courses of treatment, computed tomography showed size reduction of the pulmonary metastatic nodule and improvement of PAP. This study highlights that avelumab plus axitinib therapy is a safe and effective treatment option for metastatic renal cell carcinoma, even in patients with PAP.
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spelling pubmed-84361222021-09-17 Avelumab plus axitinib therapy for renal cell carcinoma in a patient with pulmonary alveolar proteinosis: A case report Shimizu, Nobuaki Hasumi, Masaru Muramatsu, Kazumichi Tsuji, Yusuke Takaku, Youtarou Urol Case Rep Oncology Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the abnormal accumulation of surfactant-derived substances in the lungs. To the best of our knowledge, the successful treatment of metastatic renal cell carcinoma in patients with PAP has not been reported. Here, we describe such treatment of a patient via avelumab plus axitinib therapy. After four courses of treatment, computed tomography showed size reduction of the pulmonary metastatic nodule and improvement of PAP. This study highlights that avelumab plus axitinib therapy is a safe and effective treatment option for metastatic renal cell carcinoma, even in patients with PAP. Elsevier 2021-09-09 /pmc/articles/PMC8436122/ /pubmed/34540590 http://dx.doi.org/10.1016/j.eucr.2021.101843 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Shimizu, Nobuaki
Hasumi, Masaru
Muramatsu, Kazumichi
Tsuji, Yusuke
Takaku, Youtarou
Avelumab plus axitinib therapy for renal cell carcinoma in a patient with pulmonary alveolar proteinosis: A case report
title Avelumab plus axitinib therapy for renal cell carcinoma in a patient with pulmonary alveolar proteinosis: A case report
title_full Avelumab plus axitinib therapy for renal cell carcinoma in a patient with pulmonary alveolar proteinosis: A case report
title_fullStr Avelumab plus axitinib therapy for renal cell carcinoma in a patient with pulmonary alveolar proteinosis: A case report
title_full_unstemmed Avelumab plus axitinib therapy for renal cell carcinoma in a patient with pulmonary alveolar proteinosis: A case report
title_short Avelumab plus axitinib therapy for renal cell carcinoma in a patient with pulmonary alveolar proteinosis: A case report
title_sort avelumab plus axitinib therapy for renal cell carcinoma in a patient with pulmonary alveolar proteinosis: a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436122/
https://www.ncbi.nlm.nih.gov/pubmed/34540590
http://dx.doi.org/10.1016/j.eucr.2021.101843
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