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Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia

[Image: see text] The current pharmaceutical market lacks therapeutic agents designed to modulate behavioral disturbances associated with dementia. To address this unmet medical need, we designed multifunctional ligands characterized by a nanomolar affinity for clinically relevant targets that are a...

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Detalles Bibliográficos
Autores principales:	Marcinkowska, Monika, Bucki, Adam, Sniecikowska, Joanna, Zagórska, Agnieszka, Fajkis-Zajączkowska, Nikola, Siwek, Agata, Gluch-Lutwin, Monika, Żmudzki, Paweł, Jastrzebska-Wiesek, Magdalena, Partyka, Anna, Wesołowska, Anna, Abram, Michał, Przejczowska-Pomierny, Katarzyna, Cios, Agnieszka, Wyska, Elżbieta, Mika, Kamil, Kotańska, Magdalena, Mierzejewski, Paweł, Kolaczkowski, Marcin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436213/ https://www.ncbi.nlm.nih.gov/pubmed/34436892 http://dx.doi.org/10.1021/acs.jmedchem.1c00497

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