CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK-dependent signaling

Colorectal cancer (CRC) is one of the most common malignancies worldwide. Collapsin response mediator protein 5 (CRMP5) belongs to a family of five cytosolic proteins that serve a major role in neural development. CRMP5 has been identified as a biomarker of numerous cancer types, including lung canc...

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Detalles Bibliográficos
Autores principales: Qiu, Fanghua, Yu, Lin, Liu, Daoli, Wu, Yujin, Qiu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436365/
https://www.ncbi.nlm.nih.gov/pubmed/34539851
http://dx.doi.org/10.3892/ol.2021.13008
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author Qiu, Fanghua
Yu, Lin
Liu, Daoli
Wu, Yujin
Qiu, Feng
author_facet Qiu, Fanghua
Yu, Lin
Liu, Daoli
Wu, Yujin
Qiu, Feng
author_sort Qiu, Fanghua
collection PubMed
description Colorectal cancer (CRC) is one of the most common malignancies worldwide. Collapsin response mediator protein 5 (CRMP5) belongs to a family of five cytosolic proteins that serve a major role in neural development. CRMP5 has been identified as a biomarker of numerous cancer types, including lung cancer and glioblastoma. However, the role of CRMP5 in CRC remains unclear. In the present study, CRMP5 was characterized as a novel biomarker of poor survival in CRC. CRMP5-overexpression in CRC cells promoted cell proliferation and migration while CPMP5-knockdown decreased cell growth and migration. A novel mechanism was uncovered, by which CRMP5 regulates MAPK signaling to drive CRC cell proliferation and development. Furthermore, CRMP5-overexpression induced chemotherapy resistance and tumor recurrence in CRC. Taken together, these results demonstrated the important role of CRMP5 in the development and proliferation of CRC cells and suggested that CRMP5 may be a novel therapeutic target for CRC.
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spelling pubmed-84363652021-09-17 CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK-dependent signaling Qiu, Fanghua Yu, Lin Liu, Daoli Wu, Yujin Qiu, Feng Oncol Lett Articles Colorectal cancer (CRC) is one of the most common malignancies worldwide. Collapsin response mediator protein 5 (CRMP5) belongs to a family of five cytosolic proteins that serve a major role in neural development. CRMP5 has been identified as a biomarker of numerous cancer types, including lung cancer and glioblastoma. However, the role of CRMP5 in CRC remains unclear. In the present study, CRMP5 was characterized as a novel biomarker of poor survival in CRC. CRMP5-overexpression in CRC cells promoted cell proliferation and migration while CPMP5-knockdown decreased cell growth and migration. A novel mechanism was uncovered, by which CRMP5 regulates MAPK signaling to drive CRC cell proliferation and development. Furthermore, CRMP5-overexpression induced chemotherapy resistance and tumor recurrence in CRC. Taken together, these results demonstrated the important role of CRMP5 in the development and proliferation of CRC cells and suggested that CRMP5 may be a novel therapeutic target for CRC. D.A. Spandidos 2021-11 2021-08-24 /pmc/articles/PMC8436365/ /pubmed/34539851 http://dx.doi.org/10.3892/ol.2021.13008 Text en Copyright: © Qiu et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Qiu, Fanghua
Yu, Lin
Liu, Daoli
Wu, Yujin
Qiu, Feng
CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK-dependent signaling
title CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK-dependent signaling
title_full CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK-dependent signaling
title_fullStr CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK-dependent signaling
title_full_unstemmed CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK-dependent signaling
title_short CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK-dependent signaling
title_sort crmp5 regulates cell proliferation and development of colorectal cancer via mapk-dependent signaling
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436365/
https://www.ncbi.nlm.nih.gov/pubmed/34539851
http://dx.doi.org/10.3892/ol.2021.13008
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