Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data

This post hoc analysis of the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1 (ACTT-1) shows a treatment effect of remdesivir (RDV) on progression to invasive mechanical ventilation (IMV) or death. Additionally, we create a risk profile that better predicts progression than baseline o...

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Autores principales: Paules, Catharine I, Gallagher, Shannon K, Rapaka, Rekha R, Davey, Richard T, Doernberg, Sarah B, Grossberg, Robert, Hynes, Noreen A, Ponce, Philip O, Short, William R, Voell, Jocelyn, Wang, Jing, Yang, Otto O, Wolfe, Cameron R, Lye, David C, Dodd, Lori E, Benson, Constance A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436376/
https://www.ncbi.nlm.nih.gov/pubmed/34379740
http://dx.doi.org/10.1093/cid/ciab695
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author Paules, Catharine I
Gallagher, Shannon K
Rapaka, Rekha R
Davey, Richard T
Doernberg, Sarah B
Grossberg, Robert
Hynes, Noreen A
Ponce, Philip O
Short, William R
Voell, Jocelyn
Wang, Jing
Yang, Otto O
Wolfe, Cameron R
Lye, David C
Dodd, Lori E
Benson, Constance A
author_facet Paules, Catharine I
Gallagher, Shannon K
Rapaka, Rekha R
Davey, Richard T
Doernberg, Sarah B
Grossberg, Robert
Hynes, Noreen A
Ponce, Philip O
Short, William R
Voell, Jocelyn
Wang, Jing
Yang, Otto O
Wolfe, Cameron R
Lye, David C
Dodd, Lori E
Benson, Constance A
author_sort Paules, Catharine I
collection PubMed
description This post hoc analysis of the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1 (ACTT-1) shows a treatment effect of remdesivir (RDV) on progression to invasive mechanical ventilation (IMV) or death. Additionally, we create a risk profile that better predicts progression than baseline oxygen requirement alone. The highest risk group derives the greatest treatment effect from RDV.
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spelling pubmed-84363762021-09-14 Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data Paules, Catharine I Gallagher, Shannon K Rapaka, Rekha R Davey, Richard T Doernberg, Sarah B Grossberg, Robert Hynes, Noreen A Ponce, Philip O Short, William R Voell, Jocelyn Wang, Jing Yang, Otto O Wolfe, Cameron R Lye, David C Dodd, Lori E Benson, Constance A Clin Infect Dis Brief Reports This post hoc analysis of the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1 (ACTT-1) shows a treatment effect of remdesivir (RDV) on progression to invasive mechanical ventilation (IMV) or death. Additionally, we create a risk profile that better predicts progression than baseline oxygen requirement alone. The highest risk group derives the greatest treatment effect from RDV. Oxford University Press 2021-08-11 /pmc/articles/PMC8436376/ /pubmed/34379740 http://dx.doi.org/10.1093/cid/ciab695 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
spellingShingle Brief Reports
Paules, Catharine I
Gallagher, Shannon K
Rapaka, Rekha R
Davey, Richard T
Doernberg, Sarah B
Grossberg, Robert
Hynes, Noreen A
Ponce, Philip O
Short, William R
Voell, Jocelyn
Wang, Jing
Yang, Otto O
Wolfe, Cameron R
Lye, David C
Dodd, Lori E
Benson, Constance A
Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data
title Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data
title_full Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data
title_fullStr Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data
title_full_unstemmed Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data
title_short Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data
title_sort remdesivir for the prevention of invasive mechanical ventilation or death in coronavirus disease 2019 (covid-19): a post hoc analysis of the adaptive covid-19 treatment trial-1 cohort data
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436376/
https://www.ncbi.nlm.nih.gov/pubmed/34379740
http://dx.doi.org/10.1093/cid/ciab695
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