Determining the Incidence of Asymptomatic SARS-CoV-2 Among Early Recipients of COVID-19 Vaccines (DISCOVER-COVID-19): A Prospective Cohort Study of Healthcare Workers Before, During and After Vaccination

The impact of coronavirus disease 2019 vaccination on viral characteristics of breakthrough infections is unknown. In this prospective cohort study, incidence of severe acute respiratory syndrome coronavirus 2 infection decreased following vaccination. Although asymptomatic positive tests were obser...

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Detalles Bibliográficos
Autores principales: North, Crystal M, Barczak, Amy, Goldstein, Robert H, Healy, Brian C, Finkelstein, Dianne M, Ding, Delaney D, Kim, Andy, Boucau, Julie, Shaw, Bennett, Gilbert, Rebecca F, Vyas, Tammy, Reynolds, Zahra, Siddle, Katherine J, MacInnis, Bronwyn L, Regan, James, Flynn, James P, Choudhary, Manish C, Vyas, Jatin M, Laskowski, Karl, Dighe, Anand S, Lemieux, Jacob E, Li, Jonathan Z, Baden, Lindsey R, Siedner, Mark J, Woolley, Ann E, Sacks, Chana A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436402/
https://www.ncbi.nlm.nih.gov/pubmed/34363462
http://dx.doi.org/10.1093/cid/ciab643
Descripción
Sumario:The impact of coronavirus disease 2019 vaccination on viral characteristics of breakthrough infections is unknown. In this prospective cohort study, incidence of severe acute respiratory syndrome coronavirus 2 infection decreased following vaccination. Although asymptomatic positive tests were observed following vaccination, the higher cycle thresholds, repeat negative tests, and inability to culture virus raise questions about their clinical significance.

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