Determining the Incidence of Asymptomatic SARS-CoV-2 Among Early Recipients of COVID-19 Vaccines (DISCOVER-COVID-19): A Prospective Cohort Study of Healthcare Workers Before, During and After Vaccination

The impact of coronavirus disease 2019 vaccination on viral characteristics of breakthrough infections is unknown. In this prospective cohort study, incidence of severe acute respiratory syndrome coronavirus 2 infection decreased following vaccination. Although asymptomatic positive tests were obser...

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Autores principales: North, Crystal M, Barczak, Amy, Goldstein, Robert H, Healy, Brian C, Finkelstein, Dianne M, Ding, Delaney D, Kim, Andy, Boucau, Julie, Shaw, Bennett, Gilbert, Rebecca F, Vyas, Tammy, Reynolds, Zahra, Siddle, Katherine J, MacInnis, Bronwyn L, Regan, James, Flynn, James P, Choudhary, Manish C, Vyas, Jatin M, Laskowski, Karl, Dighe, Anand S, Lemieux, Jacob E, Li, Jonathan Z, Baden, Lindsey R, Siedner, Mark J, Woolley, Ann E, Sacks, Chana A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436402/
https://www.ncbi.nlm.nih.gov/pubmed/34363462
http://dx.doi.org/10.1093/cid/ciab643
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author North, Crystal M
Barczak, Amy
Goldstein, Robert H
Healy, Brian C
Finkelstein, Dianne M
Ding, Delaney D
Kim, Andy
Boucau, Julie
Shaw, Bennett
Gilbert, Rebecca F
Vyas, Tammy
Reynolds, Zahra
Siddle, Katherine J
MacInnis, Bronwyn L
Regan, James
Flynn, James P
Choudhary, Manish C
Vyas, Jatin M
Laskowski, Karl
Dighe, Anand S
Lemieux, Jacob E
Li, Jonathan Z
Baden, Lindsey R
Siedner, Mark J
Woolley, Ann E
Sacks, Chana A
author_facet North, Crystal M
Barczak, Amy
Goldstein, Robert H
Healy, Brian C
Finkelstein, Dianne M
Ding, Delaney D
Kim, Andy
Boucau, Julie
Shaw, Bennett
Gilbert, Rebecca F
Vyas, Tammy
Reynolds, Zahra
Siddle, Katherine J
MacInnis, Bronwyn L
Regan, James
Flynn, James P
Choudhary, Manish C
Vyas, Jatin M
Laskowski, Karl
Dighe, Anand S
Lemieux, Jacob E
Li, Jonathan Z
Baden, Lindsey R
Siedner, Mark J
Woolley, Ann E
Sacks, Chana A
author_sort North, Crystal M
collection PubMed
description The impact of coronavirus disease 2019 vaccination on viral characteristics of breakthrough infections is unknown. In this prospective cohort study, incidence of severe acute respiratory syndrome coronavirus 2 infection decreased following vaccination. Although asymptomatic positive tests were observed following vaccination, the higher cycle thresholds, repeat negative tests, and inability to culture virus raise questions about their clinical significance.
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spelling pubmed-84364022021-09-14 Determining the Incidence of Asymptomatic SARS-CoV-2 Among Early Recipients of COVID-19 Vaccines (DISCOVER-COVID-19): A Prospective Cohort Study of Healthcare Workers Before, During and After Vaccination North, Crystal M Barczak, Amy Goldstein, Robert H Healy, Brian C Finkelstein, Dianne M Ding, Delaney D Kim, Andy Boucau, Julie Shaw, Bennett Gilbert, Rebecca F Vyas, Tammy Reynolds, Zahra Siddle, Katherine J MacInnis, Bronwyn L Regan, James Flynn, James P Choudhary, Manish C Vyas, Jatin M Laskowski, Karl Dighe, Anand S Lemieux, Jacob E Li, Jonathan Z Baden, Lindsey R Siedner, Mark J Woolley, Ann E Sacks, Chana A Clin Infect Dis Brief Reports The impact of coronavirus disease 2019 vaccination on viral characteristics of breakthrough infections is unknown. In this prospective cohort study, incidence of severe acute respiratory syndrome coronavirus 2 infection decreased following vaccination. Although asymptomatic positive tests were observed following vaccination, the higher cycle thresholds, repeat negative tests, and inability to culture virus raise questions about their clinical significance. Oxford University Press 2021-08-07 /pmc/articles/PMC8436402/ /pubmed/34363462 http://dx.doi.org/10.1093/cid/ciab643 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
spellingShingle Brief Reports
North, Crystal M
Barczak, Amy
Goldstein, Robert H
Healy, Brian C
Finkelstein, Dianne M
Ding, Delaney D
Kim, Andy
Boucau, Julie
Shaw, Bennett
Gilbert, Rebecca F
Vyas, Tammy
Reynolds, Zahra
Siddle, Katherine J
MacInnis, Bronwyn L
Regan, James
Flynn, James P
Choudhary, Manish C
Vyas, Jatin M
Laskowski, Karl
Dighe, Anand S
Lemieux, Jacob E
Li, Jonathan Z
Baden, Lindsey R
Siedner, Mark J
Woolley, Ann E
Sacks, Chana A
Determining the Incidence of Asymptomatic SARS-CoV-2 Among Early Recipients of COVID-19 Vaccines (DISCOVER-COVID-19): A Prospective Cohort Study of Healthcare Workers Before, During and After Vaccination
title Determining the Incidence of Asymptomatic SARS-CoV-2 Among Early Recipients of COVID-19 Vaccines (DISCOVER-COVID-19): A Prospective Cohort Study of Healthcare Workers Before, During and After Vaccination
title_full Determining the Incidence of Asymptomatic SARS-CoV-2 Among Early Recipients of COVID-19 Vaccines (DISCOVER-COVID-19): A Prospective Cohort Study of Healthcare Workers Before, During and After Vaccination
title_fullStr Determining the Incidence of Asymptomatic SARS-CoV-2 Among Early Recipients of COVID-19 Vaccines (DISCOVER-COVID-19): A Prospective Cohort Study of Healthcare Workers Before, During and After Vaccination
title_full_unstemmed Determining the Incidence of Asymptomatic SARS-CoV-2 Among Early Recipients of COVID-19 Vaccines (DISCOVER-COVID-19): A Prospective Cohort Study of Healthcare Workers Before, During and After Vaccination
title_short Determining the Incidence of Asymptomatic SARS-CoV-2 Among Early Recipients of COVID-19 Vaccines (DISCOVER-COVID-19): A Prospective Cohort Study of Healthcare Workers Before, During and After Vaccination
title_sort determining the incidence of asymptomatic sars-cov-2 among early recipients of covid-19 vaccines (discover-covid-19): a prospective cohort study of healthcare workers before, during and after vaccination
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436402/
https://www.ncbi.nlm.nih.gov/pubmed/34363462
http://dx.doi.org/10.1093/cid/ciab643
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