Structurally Optimized Potent Dual-Targeting NBTI Antibacterials with an Enhanced Bifurcated Halogen-Bonding Propensity

[Image: see text] We designed and synthesized an optimized library of novel bacterial topoisomerase inhibitors with p-halogenated phenyl right-hand side fragments and significantly enhanced and balanced dual-targeted DNA gyrase and topoisomerase IV activities of Staphylococcus aureus and Escherichia...

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Detalles Bibliográficos
Autores principales: Kokot, Maja, Weiss, Matjaž, Zdovc, Irena, Hrast, Martina, Anderluh, Marko, Minovski, Nikola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436411/
https://www.ncbi.nlm.nih.gov/pubmed/34527181
http://dx.doi.org/10.1021/acsmedchemlett.1c00345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436411/
https://www.ncbi.nlm.nih.gov/pubmed/34527181
http://dx.doi.org/10.1021/acsmedchemlett.1c00345

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