Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia

A 36-year-old woman with decompensated liver cirrhosis type C was referred to our hospital to receive antiviral treatment for hepatitis C virus (HCV). She had been diagnosed with intractable epilepsy and cerebral palsy at birth and was managed by central venous nutrition and nasal gastric feeding. A...

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Autores principales: Murayama, Aiko, Tajiri, Kazuto, Kanegane, Chiharu, Murakami, Jun, Hayashi, Yuka, Yasuda, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436629/
https://www.ncbi.nlm.nih.gov/pubmed/34594173
http://dx.doi.org/10.1159/000518306
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author Murayama, Aiko
Tajiri, Kazuto
Kanegane, Chiharu
Murakami, Jun
Hayashi, Yuka
Yasuda, Ichiro
author_facet Murayama, Aiko
Tajiri, Kazuto
Kanegane, Chiharu
Murakami, Jun
Hayashi, Yuka
Yasuda, Ichiro
author_sort Murayama, Aiko
collection PubMed
description A 36-year-old woman with decompensated liver cirrhosis type C was referred to our hospital to receive antiviral treatment for hepatitis C virus (HCV). She had been diagnosed with intractable epilepsy and cerebral palsy at birth and was managed by central venous nutrition and nasal gastric feeding. At age 34 years, she was diagnosed with thrombocytopenia, probably associated with HCV infection. She showed refractory ascites for several months and was therefore administered crushed sofosbuvir/velpatasvir tablets via a nasal gastric tube. Her HCV infection was successfully eradicated, her ascites disappeared, and thrombocytopenia improved with a marked decrease in platelet-associated IgG.
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spelling pubmed-84366292021-09-29 Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia Murayama, Aiko Tajiri, Kazuto Kanegane, Chiharu Murakami, Jun Hayashi, Yuka Yasuda, Ichiro Case Rep Gastroenterol Single Case A 36-year-old woman with decompensated liver cirrhosis type C was referred to our hospital to receive antiviral treatment for hepatitis C virus (HCV). She had been diagnosed with intractable epilepsy and cerebral palsy at birth and was managed by central venous nutrition and nasal gastric feeding. At age 34 years, she was diagnosed with thrombocytopenia, probably associated with HCV infection. She showed refractory ascites for several months and was therefore administered crushed sofosbuvir/velpatasvir tablets via a nasal gastric tube. Her HCV infection was successfully eradicated, her ascites disappeared, and thrombocytopenia improved with a marked decrease in platelet-associated IgG. S. Karger AG 2021-08-06 /pmc/articles/PMC8436629/ /pubmed/34594173 http://dx.doi.org/10.1159/000518306 Text en Copyright © 2021 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Murayama, Aiko
Tajiri, Kazuto
Kanegane, Chiharu
Murakami, Jun
Hayashi, Yuka
Yasuda, Ichiro
Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia
title Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia
title_full Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia
title_fullStr Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia
title_full_unstemmed Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia
title_short Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia
title_sort successful treatment with crushed sofosbuvir/velpatasvir of a patient with decompensated cirrhosis c and thrombocytopenia
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436629/
https://www.ncbi.nlm.nih.gov/pubmed/34594173
http://dx.doi.org/10.1159/000518306
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