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Structural insights into GIRK2 channel modulation by cholesterol and PIP(2)

G-protein-gated inwardly rectifying potassium (GIRK) channels are important for determining neuronal excitability. In addition to G proteins, GIRK channels are potentiated by membrane cholesterol, which is elevated in the brains of people with neurodegenerative diseases such as Alzheimer’s dementia...

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Detalles Bibliográficos
Autores principales:	Mathiharan, Yamuna Kalyani, Glaaser, Ian W., Zhao, Yulin, Robertson, Michael J., Skiniotis, Georgios, Slesinger, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436891/ https://www.ncbi.nlm.nih.gov/pubmed/34433062 http://dx.doi.org/10.1016/j.celrep.2021.109619

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