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Stress-induced aberrations in sensory processing predict worse cognitive outcomes in healthy aging adults

It is well recognized that not all individuals age equivalently, with functional dependence attributable, at least in part, to stress accumulated across the lifespan. Amongst these dependencies are age-related declines in cognitive function, which may be the result of impaired inhibitory processing...

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Autores principales: Spooner, Rachel K., Taylor, Brittany K., L’Heureux, Emma, Schantell, Mikki, Arif, Yasra, May, Pamela E., Morsey, Brenda, Wang, Tina, Ideker, Trey, Fox, Howard S., Wilson, Tony W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436901/
https://www.ncbi.nlm.nih.gov/pubmed/34410999
http://dx.doi.org/10.18632/aging.203433
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author Spooner, Rachel K.
Taylor, Brittany K.
L’Heureux, Emma
Schantell, Mikki
Arif, Yasra
May, Pamela E.
Morsey, Brenda
Wang, Tina
Ideker, Trey
Fox, Howard S.
Wilson, Tony W.
author_facet Spooner, Rachel K.
Taylor, Brittany K.
L’Heureux, Emma
Schantell, Mikki
Arif, Yasra
May, Pamela E.
Morsey, Brenda
Wang, Tina
Ideker, Trey
Fox, Howard S.
Wilson, Tony W.
author_sort Spooner, Rachel K.
collection PubMed
description It is well recognized that not all individuals age equivalently, with functional dependence attributable, at least in part, to stress accumulated across the lifespan. Amongst these dependencies are age-related declines in cognitive function, which may be the result of impaired inhibitory processing (e.g., sensory gating). Herein, we examined the unique roles of life and biological stress on somatosensory gating dynamics in 74 adults (22-72 years old). Participants completed a sensory gating paired-pulse electrical stimulation paradigm of the right median nerve during magnetoencephalography (MEG) and data were subjected to advanced oscillatory and time-domain analysis methods. We observed separable mechanisms by which increasing levels of life and biological stress predicted higher oscillatory gating ratios, indicative of age-related impairments in inhibitory function. Specifically, elevations in life stress significantly modulated the neural response to the first stimulation in the pair, while elevations in biological stress significantly modulated the neural response to the second stimulation in the pair. In contrast, neither elevations in life nor biological stress significantly predicted the gating of time-domain neural activity in the somatosensory cortex. Finally, our study is the first to link stress-induced decline in sensory gating to cognitive dysfunction, suggesting that gating paradigms may hold promise for detecting discrepant functional trajectories in age-related pathologies in the future.
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spelling pubmed-84369012021-09-14 Stress-induced aberrations in sensory processing predict worse cognitive outcomes in healthy aging adults Spooner, Rachel K. Taylor, Brittany K. L’Heureux, Emma Schantell, Mikki Arif, Yasra May, Pamela E. Morsey, Brenda Wang, Tina Ideker, Trey Fox, Howard S. Wilson, Tony W. Aging (Albany NY) Research Paper It is well recognized that not all individuals age equivalently, with functional dependence attributable, at least in part, to stress accumulated across the lifespan. Amongst these dependencies are age-related declines in cognitive function, which may be the result of impaired inhibitory processing (e.g., sensory gating). Herein, we examined the unique roles of life and biological stress on somatosensory gating dynamics in 74 adults (22-72 years old). Participants completed a sensory gating paired-pulse electrical stimulation paradigm of the right median nerve during magnetoencephalography (MEG) and data were subjected to advanced oscillatory and time-domain analysis methods. We observed separable mechanisms by which increasing levels of life and biological stress predicted higher oscillatory gating ratios, indicative of age-related impairments in inhibitory function. Specifically, elevations in life stress significantly modulated the neural response to the first stimulation in the pair, while elevations in biological stress significantly modulated the neural response to the second stimulation in the pair. In contrast, neither elevations in life nor biological stress significantly predicted the gating of time-domain neural activity in the somatosensory cortex. Finally, our study is the first to link stress-induced decline in sensory gating to cognitive dysfunction, suggesting that gating paradigms may hold promise for detecting discrepant functional trajectories in age-related pathologies in the future. Impact Journals 2021-08-18 /pmc/articles/PMC8436901/ /pubmed/34410999 http://dx.doi.org/10.18632/aging.203433 Text en Copyright: © 2021 Spooner et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Spooner, Rachel K.
Taylor, Brittany K.
L’Heureux, Emma
Schantell, Mikki
Arif, Yasra
May, Pamela E.
Morsey, Brenda
Wang, Tina
Ideker, Trey
Fox, Howard S.
Wilson, Tony W.
Stress-induced aberrations in sensory processing predict worse cognitive outcomes in healthy aging adults
title Stress-induced aberrations in sensory processing predict worse cognitive outcomes in healthy aging adults
title_full Stress-induced aberrations in sensory processing predict worse cognitive outcomes in healthy aging adults
title_fullStr Stress-induced aberrations in sensory processing predict worse cognitive outcomes in healthy aging adults
title_full_unstemmed Stress-induced aberrations in sensory processing predict worse cognitive outcomes in healthy aging adults
title_short Stress-induced aberrations in sensory processing predict worse cognitive outcomes in healthy aging adults
title_sort stress-induced aberrations in sensory processing predict worse cognitive outcomes in healthy aging adults
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436901/
https://www.ncbi.nlm.nih.gov/pubmed/34410999
http://dx.doi.org/10.18632/aging.203433
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