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Identification of effective natural PIK3CA H1047R inhibitors by computational study

Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer with a poor prognosis and a high recurrence rate. PIK3CA gene is frequently mutated in breast cancer, with PIK3CA H1047R as the hotspot mutation reported in TNBC. We used the ZINC database to screen natural compound...

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Detalles Bibliográficos
Autores principales:	Liu, Naimeng, Wang, Xinhui, Li, Xuan, Lv, Xiaye, Xie, Haoqun, Guo, Zhen, Wang, Jing, Dou, Gaojing, Du, Ye, Song, Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436935/ https://www.ncbi.nlm.nih.gov/pubmed/34415239 http://dx.doi.org/10.18632/aging.203409

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