Cargando…
Effect of diabetic kidney disease on therapeutic strategies for coronary artery disease: ten year follow-up
Background: The best treatment for coronary artery disease (CAD) in patients with type 2 diabetes (DM2) and chronic kidney disease is unknown. Methods: This retrospective study included MASS registry patients with DM2 and multivessel CAD, stratified by kidney function. Primary endpoint was combined...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436946/ https://www.ncbi.nlm.nih.gov/pubmed/34433133 http://dx.doi.org/10.18632/aging.203476 |
_version_ | 1783752081012686848 |
---|---|
author | Batista, Daniel Valente Hueb, Whady Lima, Eduardo Gomes Rezende, Paulo Cury Garzillo, Cibele Larrosa Garcia, Rosa Maria Rahmi Filho, Jaime Paula Pessoa Linhares Martins, Eduardo Bello Junior, Carlos Vicente Serrano Ramires, Jose Antonio Franchini Filho, Roberto Kalil |
author_facet | Batista, Daniel Valente Hueb, Whady Lima, Eduardo Gomes Rezende, Paulo Cury Garzillo, Cibele Larrosa Garcia, Rosa Maria Rahmi Filho, Jaime Paula Pessoa Linhares Martins, Eduardo Bello Junior, Carlos Vicente Serrano Ramires, Jose Antonio Franchini Filho, Roberto Kalil |
author_sort | Batista, Daniel Valente |
collection | PubMed |
description | Background: The best treatment for coronary artery disease (CAD) in patients with type 2 diabetes (DM2) and chronic kidney disease is unknown. Methods: This retrospective study included MASS registry patients with DM2 and multivessel CAD, stratified by kidney function. Primary endpoint was combined of mortality, myocardial infarction, or additional revascularization. Results: Median follow-up was 9.5 years. Primary endpoint occurrences among strata 1 and 2 were 53.4% and 40.7%, respectively (P=.020). Mortality rates were 37.4% and 24.6% in strata 1 and 2, respectively (P<.001). We observed a lower rate of major adverse cardiovascular events (MACE) (P=.027 for stratum 1 and P<.001 for stratum 2) and additional revascularization (P=.001 for stratum 1 and P<.001 for stratum 2) for those in the surgical group. In a multivariate analysis, eGFR was an independent predictor of MACE (P=.034) and mortality (P=.020). Conclusions: Among subjects with DM2 and CAD the presence of lower eGFR rate was associated with higher rates of MACE and mortality, irrespective of treatment choice. CABG was associated with lower rates of MACE in both renal function strata. eGFR was an independent predictor of MACE and mortality in a 10-year follow-up. |
format | Online Article Text |
id | pubmed-8436946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-84369462021-09-14 Effect of diabetic kidney disease on therapeutic strategies for coronary artery disease: ten year follow-up Batista, Daniel Valente Hueb, Whady Lima, Eduardo Gomes Rezende, Paulo Cury Garzillo, Cibele Larrosa Garcia, Rosa Maria Rahmi Filho, Jaime Paula Pessoa Linhares Martins, Eduardo Bello Junior, Carlos Vicente Serrano Ramires, Jose Antonio Franchini Filho, Roberto Kalil Aging (Albany NY) Research Paper Background: The best treatment for coronary artery disease (CAD) in patients with type 2 diabetes (DM2) and chronic kidney disease is unknown. Methods: This retrospective study included MASS registry patients with DM2 and multivessel CAD, stratified by kidney function. Primary endpoint was combined of mortality, myocardial infarction, or additional revascularization. Results: Median follow-up was 9.5 years. Primary endpoint occurrences among strata 1 and 2 were 53.4% and 40.7%, respectively (P=.020). Mortality rates were 37.4% and 24.6% in strata 1 and 2, respectively (P<.001). We observed a lower rate of major adverse cardiovascular events (MACE) (P=.027 for stratum 1 and P<.001 for stratum 2) and additional revascularization (P=.001 for stratum 1 and P<.001 for stratum 2) for those in the surgical group. In a multivariate analysis, eGFR was an independent predictor of MACE (P=.034) and mortality (P=.020). Conclusions: Among subjects with DM2 and CAD the presence of lower eGFR rate was associated with higher rates of MACE and mortality, irrespective of treatment choice. CABG was associated with lower rates of MACE in both renal function strata. eGFR was an independent predictor of MACE and mortality in a 10-year follow-up. Impact Journals 2021-08-25 /pmc/articles/PMC8436946/ /pubmed/34433133 http://dx.doi.org/10.18632/aging.203476 Text en Copyright: © 2021 Batista et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Batista, Daniel Valente Hueb, Whady Lima, Eduardo Gomes Rezende, Paulo Cury Garzillo, Cibele Larrosa Garcia, Rosa Maria Rahmi Filho, Jaime Paula Pessoa Linhares Martins, Eduardo Bello Junior, Carlos Vicente Serrano Ramires, Jose Antonio Franchini Filho, Roberto Kalil Effect of diabetic kidney disease on therapeutic strategies for coronary artery disease: ten year follow-up |
title | Effect of diabetic kidney disease on therapeutic strategies for coronary artery disease: ten year follow-up |
title_full | Effect of diabetic kidney disease on therapeutic strategies for coronary artery disease: ten year follow-up |
title_fullStr | Effect of diabetic kidney disease on therapeutic strategies for coronary artery disease: ten year follow-up |
title_full_unstemmed | Effect of diabetic kidney disease on therapeutic strategies for coronary artery disease: ten year follow-up |
title_short | Effect of diabetic kidney disease on therapeutic strategies for coronary artery disease: ten year follow-up |
title_sort | effect of diabetic kidney disease on therapeutic strategies for coronary artery disease: ten year follow-up |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436946/ https://www.ncbi.nlm.nih.gov/pubmed/34433133 http://dx.doi.org/10.18632/aging.203476 |
work_keys_str_mv | AT batistadanielvalente effectofdiabetickidneydiseaseontherapeuticstrategiesforcoronaryarterydiseasetenyearfollowup AT huebwhady effectofdiabetickidneydiseaseontherapeuticstrategiesforcoronaryarterydiseasetenyearfollowup AT limaeduardogomes effectofdiabetickidneydiseaseontherapeuticstrategiesforcoronaryarterydiseasetenyearfollowup AT rezendepaulocury effectofdiabetickidneydiseaseontherapeuticstrategiesforcoronaryarterydiseasetenyearfollowup AT garzillocibelelarrosa effectofdiabetickidneydiseaseontherapeuticstrategiesforcoronaryarterydiseasetenyearfollowup AT garciarosamariarahmi effectofdiabetickidneydiseaseontherapeuticstrategiesforcoronaryarterydiseasetenyearfollowup AT filhojaimepaulapessoalinhares effectofdiabetickidneydiseaseontherapeuticstrategiesforcoronaryarterydiseasetenyearfollowup AT martinseduardobello effectofdiabetickidneydiseaseontherapeuticstrategiesforcoronaryarterydiseasetenyearfollowup AT juniorcarlosvicenteserrano effectofdiabetickidneydiseaseontherapeuticstrategiesforcoronaryarterydiseasetenyearfollowup AT ramiresjoseantoniofranchini effectofdiabetickidneydiseaseontherapeuticstrategiesforcoronaryarterydiseasetenyearfollowup AT filhorobertokalil effectofdiabetickidneydiseaseontherapeuticstrategiesforcoronaryarterydiseasetenyearfollowup |