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Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility
Polysulfone (PSF) works potentially in haemodialysis due to its great mechanical and chemical stability, but performs poorly in haemocompatibility. For promoting the unpleasant haemocompatibility, sulfonated citric chitosan (SCACS) with the structure and groups similar to heparin was primarily synth...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437023/ https://www.ncbi.nlm.nih.gov/pubmed/34540249 http://dx.doi.org/10.1098/rsos.210462 |
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author | Lin, Bingxian Liu, Kaiming Qiu, Yunren |
author_facet | Lin, Bingxian Liu, Kaiming Qiu, Yunren |
author_sort | Lin, Bingxian |
collection | PubMed |
description | Polysulfone (PSF) works potentially in haemodialysis due to its great mechanical and chemical stability, but performs poorly in haemocompatibility. For promoting the unpleasant haemocompatibility, sulfonated citric chitosan (SCACS) with the structure and groups similar to heparin was primarily synthesized by acylation and sulfonation. Furthermore, the chloroacylated PSF was pretreated by electrophilic chloroacetyl chloride to achieve more active sites for further reaction; the following membranes underwent the amination and were named amination polysulfone (AMPSF) membranes. Moreover, SCACS with abundant carboxyl and sulfonic groups was covalently grafted at the surface of pretreated PSF membranes, called PSF-SCACS membranes. The PSF-SCACS membranes were successfully synthesized and characterized by (1)H NMR, ATR-FTIR and XPS. In addition, the water contact angle of PSF-SCACS membranes decreased by 47° and the morphologies of the membranes changed little compared with the unmodified PSF membranes. The haemocompatible testing results, including protein adsorption, platelet adhesion, haemolysis rate, plasma recalcification time, activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT), demonstrated that the PSF-SCACS membranes possessed excellent haemocompatible performances, and SCACS played an important role in the modification. |
format | Online Article Text |
id | pubmed-8437023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-84370232021-09-17 Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility Lin, Bingxian Liu, Kaiming Qiu, Yunren R Soc Open Sci Chemistry Polysulfone (PSF) works potentially in haemodialysis due to its great mechanical and chemical stability, but performs poorly in haemocompatibility. For promoting the unpleasant haemocompatibility, sulfonated citric chitosan (SCACS) with the structure and groups similar to heparin was primarily synthesized by acylation and sulfonation. Furthermore, the chloroacylated PSF was pretreated by electrophilic chloroacetyl chloride to achieve more active sites for further reaction; the following membranes underwent the amination and were named amination polysulfone (AMPSF) membranes. Moreover, SCACS with abundant carboxyl and sulfonic groups was covalently grafted at the surface of pretreated PSF membranes, called PSF-SCACS membranes. The PSF-SCACS membranes were successfully synthesized and characterized by (1)H NMR, ATR-FTIR and XPS. In addition, the water contact angle of PSF-SCACS membranes decreased by 47° and the morphologies of the membranes changed little compared with the unmodified PSF membranes. The haemocompatible testing results, including protein adsorption, platelet adhesion, haemolysis rate, plasma recalcification time, activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT), demonstrated that the PSF-SCACS membranes possessed excellent haemocompatible performances, and SCACS played an important role in the modification. The Royal Society 2021-09-08 /pmc/articles/PMC8437023/ /pubmed/34540249 http://dx.doi.org/10.1098/rsos.210462 Text en © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Chemistry Lin, Bingxian Liu, Kaiming Qiu, Yunren Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility |
title | Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility |
title_full | Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility |
title_fullStr | Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility |
title_full_unstemmed | Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility |
title_short | Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility |
title_sort | preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437023/ https://www.ncbi.nlm.nih.gov/pubmed/34540249 http://dx.doi.org/10.1098/rsos.210462 |
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