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High extracellular phosphate increases platelet polyphosphate content

Platelet-derived extracellular polyphosphate (PolyP) is a major mediator of thrombosis. PolyP is a linear chain of inorganic phosphate (P(i)) and is stored in platelet dense granules. P(i) enters cells from the extracellular fluid through phosphate transporters and may be stored as PolyP. Here we sh...

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Detalles Bibliográficos
Autores principales: Abbasian, Nima, Harper, Matthew T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437092/
https://www.ncbi.nlm.nih.gov/pubmed/32892685
http://dx.doi.org/10.1080/09537104.2020.1817358
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author Abbasian, Nima
Harper, Matthew T.
author_facet Abbasian, Nima
Harper, Matthew T.
author_sort Abbasian, Nima
collection PubMed
description Platelet-derived extracellular polyphosphate (PolyP) is a major mediator of thrombosis. PolyP is a linear chain of inorganic phosphate (P(i)) and is stored in platelet dense granules. P(i) enters cells from the extracellular fluid through phosphate transporters and may be stored as PolyP. Here we show that high extracellular P(i) concentration in vitro increases platelet PolyP content, in a manner dependent on phosphate transporters, IP6K and V-type ATPases. The increased PolyP also enhanced PolyP-dependent coagulation in platelet-rich plasma. These data suggest a mechanistic link between hyperphosphatemia, PolyP and enhanced coagulation, which may be important in pathologies such as chronic kidney disease.
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spelling pubmed-84370922021-09-14 High extracellular phosphate increases platelet polyphosphate content Abbasian, Nima Harper, Matthew T. Platelets Brief Report Platelet-derived extracellular polyphosphate (PolyP) is a major mediator of thrombosis. PolyP is a linear chain of inorganic phosphate (P(i)) and is stored in platelet dense granules. P(i) enters cells from the extracellular fluid through phosphate transporters and may be stored as PolyP. Here we show that high extracellular P(i) concentration in vitro increases platelet PolyP content, in a manner dependent on phosphate transporters, IP6K and V-type ATPases. The increased PolyP also enhanced PolyP-dependent coagulation in platelet-rich plasma. These data suggest a mechanistic link between hyperphosphatemia, PolyP and enhanced coagulation, which may be important in pathologies such as chronic kidney disease. Taylor & Francis 2020-09-06 /pmc/articles/PMC8437092/ /pubmed/32892685 http://dx.doi.org/10.1080/09537104.2020.1817358 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Abbasian, Nima
Harper, Matthew T.
High extracellular phosphate increases platelet polyphosphate content
title High extracellular phosphate increases platelet polyphosphate content
title_full High extracellular phosphate increases platelet polyphosphate content
title_fullStr High extracellular phosphate increases platelet polyphosphate content
title_full_unstemmed High extracellular phosphate increases platelet polyphosphate content
title_short High extracellular phosphate increases platelet polyphosphate content
title_sort high extracellular phosphate increases platelet polyphosphate content
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437092/
https://www.ncbi.nlm.nih.gov/pubmed/32892685
http://dx.doi.org/10.1080/09537104.2020.1817358
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