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Seroprevalence of Zika virus in pregnant women from central Thailand

Zika virus (ZKV) infection in a pregnant woman, especially during the first trimester, often results in congenital anomalies. However, the pathogenic mechanism is unknown and one-third of ZKV infected pregnancies are asymptomatic. Neutralizing antibodies against ZKV has been reported in 70% of Thai...

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Autores principales: Phatihattakorn, Chayawat, Wongsa, Artit, Pongpan, Kirakorn, Anuwuthinawin, Sanitra, Mungmanthong, Sakita, Wongprasert, Manthana, Tassaneetrithep, Boonrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437263/
https://www.ncbi.nlm.nih.gov/pubmed/34516583
http://dx.doi.org/10.1371/journal.pone.0257205
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author Phatihattakorn, Chayawat
Wongsa, Artit
Pongpan, Kirakorn
Anuwuthinawin, Sanitra
Mungmanthong, Sakita
Wongprasert, Manthana
Tassaneetrithep, Boonrat
author_facet Phatihattakorn, Chayawat
Wongsa, Artit
Pongpan, Kirakorn
Anuwuthinawin, Sanitra
Mungmanthong, Sakita
Wongprasert, Manthana
Tassaneetrithep, Boonrat
author_sort Phatihattakorn, Chayawat
collection PubMed
description Zika virus (ZKV) infection in a pregnant woman, especially during the first trimester, often results in congenital anomalies. However, the pathogenic mechanism is unknown and one-third of ZKV infected pregnancies are asymptomatic. Neutralizing antibodies against ZKV has been reported in 70% of Thai adults, but the prevalence among pregnant women is unknown. Currently, vaccines and specific treatments for ZKV are under development. A better understanding of the immune status of pregnant women will increase the success of effective prevention guidelines. The prevalence of ZKV infection in pregnant women in antenatal care clinics was investigated during the rainy season from May to October 2019 at Siriraj Hospital, Bangkok, Thailand. We recruited 650 pregnant women (39.42% first, 52.26% second and 7.36% third trimester) and found that 30.77% had ZKV-specific IgG, and 39.81% had neutralizing antibodies (nAb) against ZKV (titer ≥10). Specific and neutralizing antibody levels varied by maternal age, trimester, and month. We further characterized the cross-reaction between ZKV and the four Dengue virus (DENV) serotypes by focused reduction neutralization test (FRNT) and found that cross-reactions were common. In conclusion, about 60% of pregnant women who living in central Thailand may be at risk of ZKV infection due to the absence of neutralizing antibodies against ZKV. The functions of cross-reactive antibodies between related viral genotypes require further study. These findings have implications for health care monitoring in pregnant women including determining the risk of ZKV infection, assisting the development of a flavivirus vaccine, and informing the development of preventative health policies.
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spelling pubmed-84372632021-09-14 Seroprevalence of Zika virus in pregnant women from central Thailand Phatihattakorn, Chayawat Wongsa, Artit Pongpan, Kirakorn Anuwuthinawin, Sanitra Mungmanthong, Sakita Wongprasert, Manthana Tassaneetrithep, Boonrat PLoS One Research Article Zika virus (ZKV) infection in a pregnant woman, especially during the first trimester, often results in congenital anomalies. However, the pathogenic mechanism is unknown and one-third of ZKV infected pregnancies are asymptomatic. Neutralizing antibodies against ZKV has been reported in 70% of Thai adults, but the prevalence among pregnant women is unknown. Currently, vaccines and specific treatments for ZKV are under development. A better understanding of the immune status of pregnant women will increase the success of effective prevention guidelines. The prevalence of ZKV infection in pregnant women in antenatal care clinics was investigated during the rainy season from May to October 2019 at Siriraj Hospital, Bangkok, Thailand. We recruited 650 pregnant women (39.42% first, 52.26% second and 7.36% third trimester) and found that 30.77% had ZKV-specific IgG, and 39.81% had neutralizing antibodies (nAb) against ZKV (titer ≥10). Specific and neutralizing antibody levels varied by maternal age, trimester, and month. We further characterized the cross-reaction between ZKV and the four Dengue virus (DENV) serotypes by focused reduction neutralization test (FRNT) and found that cross-reactions were common. In conclusion, about 60% of pregnant women who living in central Thailand may be at risk of ZKV infection due to the absence of neutralizing antibodies against ZKV. The functions of cross-reactive antibodies between related viral genotypes require further study. These findings have implications for health care monitoring in pregnant women including determining the risk of ZKV infection, assisting the development of a flavivirus vaccine, and informing the development of preventative health policies. Public Library of Science 2021-09-13 /pmc/articles/PMC8437263/ /pubmed/34516583 http://dx.doi.org/10.1371/journal.pone.0257205 Text en © 2021 Phatihattakorn et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Phatihattakorn, Chayawat
Wongsa, Artit
Pongpan, Kirakorn
Anuwuthinawin, Sanitra
Mungmanthong, Sakita
Wongprasert, Manthana
Tassaneetrithep, Boonrat
Seroprevalence of Zika virus in pregnant women from central Thailand
title Seroprevalence of Zika virus in pregnant women from central Thailand
title_full Seroprevalence of Zika virus in pregnant women from central Thailand
title_fullStr Seroprevalence of Zika virus in pregnant women from central Thailand
title_full_unstemmed Seroprevalence of Zika virus in pregnant women from central Thailand
title_short Seroprevalence of Zika virus in pregnant women from central Thailand
title_sort seroprevalence of zika virus in pregnant women from central thailand
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437263/
https://www.ncbi.nlm.nih.gov/pubmed/34516583
http://dx.doi.org/10.1371/journal.pone.0257205
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