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Hepatobiliary phase signal intensity: A potential method of diagnosing HCC with atypical imaging features among LR-M observations

Herein, we assessed whether hepatobiliary phase (HBP) signal intensity (SI) can be used to differentiate HCC and non-HCC malignancies within LR-M observations. 106 LR-M patients based on LI-RADS v2018 who underwent gadoxetate-disodium magnetic resonance imaging and surgery from January 2009 to Decem...

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Autores principales: Park, Jae Hyon, Chung, Yong Eun, Seo, Nieun, Choi, Jin-Young, Park, Mi-Suk, Kim, Myeong-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437291/
https://www.ncbi.nlm.nih.gov/pubmed/34516587
http://dx.doi.org/10.1371/journal.pone.0257308
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author Park, Jae Hyon
Chung, Yong Eun
Seo, Nieun
Choi, Jin-Young
Park, Mi-Suk
Kim, Myeong-Jin
author_facet Park, Jae Hyon
Chung, Yong Eun
Seo, Nieun
Choi, Jin-Young
Park, Mi-Suk
Kim, Myeong-Jin
author_sort Park, Jae Hyon
collection PubMed
description Herein, we assessed whether hepatobiliary phase (HBP) signal intensity (SI) can be used to differentiate HCC and non-HCC malignancies within LR-M observations. 106 LR-M patients based on LI-RADS v2018 who underwent gadoxetate-disodium magnetic resonance imaging and surgery from January 2009 to December 2018 were included. SI of LR-M observation on HBP was analyzed by two radiologists and categorized into dark, low and iso-to-high groups. Tumor was classified as dark when more than 50% of tumor showed hypointensity compared to spleen, as low when more than 50% of tumor showed hyperintensity compared to spleen but hypointensity compared to liver parenchyma, and as iso-to-high if there was even a focal iso-intensity or hyperintensity compared to liver parenchyma. Analysis of clinicopathological factors and association between imaging and histology was performed. Out of 106 LR-M, 42 (40%) were showed dark, 61 (58%) showed low, and 3 (3%) showed iso-to-high SI in HBP. Three iso-to-high SI LR-M were HCCs (P = 0.060) and their major histologic differentiation was Edmondson grade 1 (P = 0.001). 43 out of 61 (71%) low SI LR-M were iCCA or cHCC-CCA (P = 0.002). Inter-reader agreement of HBP SI classification was excellent, with a kappa coefficient of 0.872. LR-M with iso-to-high SI in HBP is prone to being HCC while LR-M with low SI in HBP is prone to being tumor with fibrous stroma such as iCCA and cHCC-CCA. Classification of LR-M based on HBP SI may be a helpful method of differentiating HCC from non-HCC malignancies.
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spelling pubmed-84372912021-09-14 Hepatobiliary phase signal intensity: A potential method of diagnosing HCC with atypical imaging features among LR-M observations Park, Jae Hyon Chung, Yong Eun Seo, Nieun Choi, Jin-Young Park, Mi-Suk Kim, Myeong-Jin PLoS One Research Article Herein, we assessed whether hepatobiliary phase (HBP) signal intensity (SI) can be used to differentiate HCC and non-HCC malignancies within LR-M observations. 106 LR-M patients based on LI-RADS v2018 who underwent gadoxetate-disodium magnetic resonance imaging and surgery from January 2009 to December 2018 were included. SI of LR-M observation on HBP was analyzed by two radiologists and categorized into dark, low and iso-to-high groups. Tumor was classified as dark when more than 50% of tumor showed hypointensity compared to spleen, as low when more than 50% of tumor showed hyperintensity compared to spleen but hypointensity compared to liver parenchyma, and as iso-to-high if there was even a focal iso-intensity or hyperintensity compared to liver parenchyma. Analysis of clinicopathological factors and association between imaging and histology was performed. Out of 106 LR-M, 42 (40%) were showed dark, 61 (58%) showed low, and 3 (3%) showed iso-to-high SI in HBP. Three iso-to-high SI LR-M were HCCs (P = 0.060) and their major histologic differentiation was Edmondson grade 1 (P = 0.001). 43 out of 61 (71%) low SI LR-M were iCCA or cHCC-CCA (P = 0.002). Inter-reader agreement of HBP SI classification was excellent, with a kappa coefficient of 0.872. LR-M with iso-to-high SI in HBP is prone to being HCC while LR-M with low SI in HBP is prone to being tumor with fibrous stroma such as iCCA and cHCC-CCA. Classification of LR-M based on HBP SI may be a helpful method of differentiating HCC from non-HCC malignancies. Public Library of Science 2021-09-13 /pmc/articles/PMC8437291/ /pubmed/34516587 http://dx.doi.org/10.1371/journal.pone.0257308 Text en © 2021 Park et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Park, Jae Hyon
Chung, Yong Eun
Seo, Nieun
Choi, Jin-Young
Park, Mi-Suk
Kim, Myeong-Jin
Hepatobiliary phase signal intensity: A potential method of diagnosing HCC with atypical imaging features among LR-M observations
title Hepatobiliary phase signal intensity: A potential method of diagnosing HCC with atypical imaging features among LR-M observations
title_full Hepatobiliary phase signal intensity: A potential method of diagnosing HCC with atypical imaging features among LR-M observations
title_fullStr Hepatobiliary phase signal intensity: A potential method of diagnosing HCC with atypical imaging features among LR-M observations
title_full_unstemmed Hepatobiliary phase signal intensity: A potential method of diagnosing HCC with atypical imaging features among LR-M observations
title_short Hepatobiliary phase signal intensity: A potential method of diagnosing HCC with atypical imaging features among LR-M observations
title_sort hepatobiliary phase signal intensity: a potential method of diagnosing hcc with atypical imaging features among lr-m observations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437291/
https://www.ncbi.nlm.nih.gov/pubmed/34516587
http://dx.doi.org/10.1371/journal.pone.0257308
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