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The Anticancer Potential of Maslinic Acid and Its Derivatives: A Review

Cancer is still an insurmountable problem for humans and critically attacking human health. In recent years, natural products have gained increasing attention in the field of anti-tumor due to their extensive sources and minimal side effects. Maslinic acid (MA), a pentacyclic triterpene acid mainly...

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Autores principales: Yu, Lei, Xie, Xiaofang, Cao, Xiaoyu, Chen, Junren, Chen, Guanru, Chen, Yan, Li, Gangmin, Qin, Junyuan, Peng, Fu, Peng, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437384/
https://www.ncbi.nlm.nih.gov/pubmed/34526766
http://dx.doi.org/10.2147/DDDT.S326328
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author Yu, Lei
Xie, Xiaofang
Cao, Xiaoyu
Chen, Junren
Chen, Guanru
Chen, Yan
Li, Gangmin
Qin, Junyuan
Peng, Fu
Peng, Cheng
author_facet Yu, Lei
Xie, Xiaofang
Cao, Xiaoyu
Chen, Junren
Chen, Guanru
Chen, Yan
Li, Gangmin
Qin, Junyuan
Peng, Fu
Peng, Cheng
author_sort Yu, Lei
collection PubMed
description Cancer is still an insurmountable problem for humans and critically attacking human health. In recent years, natural products have gained increasing attention in the field of anti-tumor due to their extensive sources and minimal side effects. Maslinic acid (MA), a pentacyclic triterpene acid mainly derived from the olive tree (Olea europaea L.) has been confirmed to possess great anti-cancer effects. This paper reviewed the inhibitory effect of MA and its derivatives on lung cancer, colon cancer, ovarian cancer, gastric cancer, lymphatic, leukemia, breast cancer, pancreatic cancer, melanoma, prostate cancer, renal cell carcinoma, gallbladder cancer, and bladder cancer, among others. MA inhibited the proliferation of various tumor cells and showed lower IC(50) values in melanoma 518A2 cells and gastric cancer MKN28 cells compared with other cell lines. A series of semi-synthetic derivatives obtained by modifying MA chemical structure have been shown to have high cytotoxicity to human tumor cell lines, but low cytotoxicity to non-malignant cells, which is conducive to developing its potential as a chemotherapeutic agent. These studies suggest that MA derivatives have broad prospects in the development of antitumor therapeutics in the future and warrant further study.
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spelling pubmed-84373842021-09-14 The Anticancer Potential of Maslinic Acid and Its Derivatives: A Review Yu, Lei Xie, Xiaofang Cao, Xiaoyu Chen, Junren Chen, Guanru Chen, Yan Li, Gangmin Qin, Junyuan Peng, Fu Peng, Cheng Drug Des Devel Ther Review Cancer is still an insurmountable problem for humans and critically attacking human health. In recent years, natural products have gained increasing attention in the field of anti-tumor due to their extensive sources and minimal side effects. Maslinic acid (MA), a pentacyclic triterpene acid mainly derived from the olive tree (Olea europaea L.) has been confirmed to possess great anti-cancer effects. This paper reviewed the inhibitory effect of MA and its derivatives on lung cancer, colon cancer, ovarian cancer, gastric cancer, lymphatic, leukemia, breast cancer, pancreatic cancer, melanoma, prostate cancer, renal cell carcinoma, gallbladder cancer, and bladder cancer, among others. MA inhibited the proliferation of various tumor cells and showed lower IC(50) values in melanoma 518A2 cells and gastric cancer MKN28 cells compared with other cell lines. A series of semi-synthetic derivatives obtained by modifying MA chemical structure have been shown to have high cytotoxicity to human tumor cell lines, but low cytotoxicity to non-malignant cells, which is conducive to developing its potential as a chemotherapeutic agent. These studies suggest that MA derivatives have broad prospects in the development of antitumor therapeutics in the future and warrant further study. Dove 2021-09-09 /pmc/articles/PMC8437384/ /pubmed/34526766 http://dx.doi.org/10.2147/DDDT.S326328 Text en © 2021 Yu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Yu, Lei
Xie, Xiaofang
Cao, Xiaoyu
Chen, Junren
Chen, Guanru
Chen, Yan
Li, Gangmin
Qin, Junyuan
Peng, Fu
Peng, Cheng
The Anticancer Potential of Maslinic Acid and Its Derivatives: A Review
title The Anticancer Potential of Maslinic Acid and Its Derivatives: A Review
title_full The Anticancer Potential of Maslinic Acid and Its Derivatives: A Review
title_fullStr The Anticancer Potential of Maslinic Acid and Its Derivatives: A Review
title_full_unstemmed The Anticancer Potential of Maslinic Acid and Its Derivatives: A Review
title_short The Anticancer Potential of Maslinic Acid and Its Derivatives: A Review
title_sort anticancer potential of maslinic acid and its derivatives: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437384/
https://www.ncbi.nlm.nih.gov/pubmed/34526766
http://dx.doi.org/10.2147/DDDT.S326328
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