Accumulation of Succinyl Coenzyme A Perturbs the Methicillin-Resistant Staphylococcus aureus (MRSA) Succinylome and Is Associated with Increased Susceptibility to Beta-Lactam Antibiotics

Penicillin binding protein 2a (PBP2a)-dependent resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is regulated by the activity of the tricarboxylic acid (TCA) cycle via a poorly understood mechanism. We report that mutations in sucC and sucD, but not other TCA...

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Detalles Bibliográficos
Autores principales: Campbell, Christopher, Fingleton, Claire, Zeden, Merve S., Bueno, Emilio, Gallagher, Laura A., Shinde, Dhananjay, Ahn, Jongsam, Olson, Heather M., Fillmore, Thomas L., Adkins, Joshua N., Razvi, Fareha, Bayles, Kenneth W., Fey, Paul D., Thomas, Vinai C., Cava, Felipe, Clair, Geremy C., O’Gara, James P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437408/
https://www.ncbi.nlm.nih.gov/pubmed/34182779
http://dx.doi.org/10.1128/mBio.00530-21

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