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Development of a New Patient-Reported Medication Adherence Instrument: Concerns Influencing Medication Adherence
PURPOSE: The purpose of this research was to conceptualize and develop a tool for identifying persons who are, or are likely to be, non-adherent to medications prescribed by their healthcare provider(s) by identifying concerns that patients have regarding their treatments. PATIENTS AND METHODS: The...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437415/ https://www.ncbi.nlm.nih.gov/pubmed/34526767 http://dx.doi.org/10.2147/PPA.S318030 |
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author | Mansukhani, Sonal Ghura MacLean, Elizabeth A Manzey, Laura L Possidente, Carl J Cappelleri, Joseph C Deal, Linda S |
author_facet | Mansukhani, Sonal Ghura MacLean, Elizabeth A Manzey, Laura L Possidente, Carl J Cappelleri, Joseph C Deal, Linda S |
author_sort | Mansukhani, Sonal Ghura |
collection | PubMed |
description | PURPOSE: The purpose of this research was to conceptualize and develop a tool for identifying persons who are, or are likely to be, non-adherent to medications prescribed by their healthcare provider(s) by identifying concerns that patients have regarding their treatments. PATIENTS AND METHODS: The target populations were persons diagnosed with atrial fibrillation or osteoarthritis, who were prescribed anticoagulants or over-the-counter or prescription pain medications, respectively. In this two-stage, multi-year, qualitative research study, relevant concepts were explored, confirmed and refined. The focus was on non-adherence due to active (thus potentially modifiable) patient decisions to forego taking medications as prescribed. RESULTS: The most common concerns among participants with atrial fibrillation were medication-related side effects and fear of bleeding. Participants with osteoarthritis were most concerned about short-term stomach problems and long-term kidney and liver side effects. The Concerns Influencing Medication Adherence (CIMA) instrument was developed based on these concerns and those identified in the literature. It is comprised of 16 items: a core set of 11 items potentially applicable to multiple disease states, 3 items specific to atrial fibrillation, and 2 items unique to osteoarthritis. The instrument is intended to be completed electronically, and publicly available for use in direct patient care in the United States or in population health management. CONCLUSION: To our knowledge, this is the first instrument focused on medication adherence that includes documented details of patient input as recommended by the United States Food and Drug Administration guidance. Patient input is considered a key component of content validity. In this research, for example, the concerns that patients have regarding their treatments can be expected to have affected past medication adherence and can potentially impact future adherence. Although applicability outside atrial fibrillation or osteoarthritis was not assessed, the general items may be useful in assessing adherence in other chronic diseases. |
format | Online Article Text |
id | pubmed-8437415 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-84374152021-09-14 Development of a New Patient-Reported Medication Adherence Instrument: Concerns Influencing Medication Adherence Mansukhani, Sonal Ghura MacLean, Elizabeth A Manzey, Laura L Possidente, Carl J Cappelleri, Joseph C Deal, Linda S Patient Prefer Adherence Original Research PURPOSE: The purpose of this research was to conceptualize and develop a tool for identifying persons who are, or are likely to be, non-adherent to medications prescribed by their healthcare provider(s) by identifying concerns that patients have regarding their treatments. PATIENTS AND METHODS: The target populations were persons diagnosed with atrial fibrillation or osteoarthritis, who were prescribed anticoagulants or over-the-counter or prescription pain medications, respectively. In this two-stage, multi-year, qualitative research study, relevant concepts were explored, confirmed and refined. The focus was on non-adherence due to active (thus potentially modifiable) patient decisions to forego taking medications as prescribed. RESULTS: The most common concerns among participants with atrial fibrillation were medication-related side effects and fear of bleeding. Participants with osteoarthritis were most concerned about short-term stomach problems and long-term kidney and liver side effects. The Concerns Influencing Medication Adherence (CIMA) instrument was developed based on these concerns and those identified in the literature. It is comprised of 16 items: a core set of 11 items potentially applicable to multiple disease states, 3 items specific to atrial fibrillation, and 2 items unique to osteoarthritis. The instrument is intended to be completed electronically, and publicly available for use in direct patient care in the United States or in population health management. CONCLUSION: To our knowledge, this is the first instrument focused on medication adherence that includes documented details of patient input as recommended by the United States Food and Drug Administration guidance. Patient input is considered a key component of content validity. In this research, for example, the concerns that patients have regarding their treatments can be expected to have affected past medication adherence and can potentially impact future adherence. Although applicability outside atrial fibrillation or osteoarthritis was not assessed, the general items may be useful in assessing adherence in other chronic diseases. Dove 2021-09-09 /pmc/articles/PMC8437415/ /pubmed/34526767 http://dx.doi.org/10.2147/PPA.S318030 Text en © 2021 Mansukhani et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Mansukhani, Sonal Ghura MacLean, Elizabeth A Manzey, Laura L Possidente, Carl J Cappelleri, Joseph C Deal, Linda S Development of a New Patient-Reported Medication Adherence Instrument: Concerns Influencing Medication Adherence |
title | Development of a New Patient-Reported Medication Adherence Instrument: Concerns Influencing Medication Adherence |
title_full | Development of a New Patient-Reported Medication Adherence Instrument: Concerns Influencing Medication Adherence |
title_fullStr | Development of a New Patient-Reported Medication Adherence Instrument: Concerns Influencing Medication Adherence |
title_full_unstemmed | Development of a New Patient-Reported Medication Adherence Instrument: Concerns Influencing Medication Adherence |
title_short | Development of a New Patient-Reported Medication Adherence Instrument: Concerns Influencing Medication Adherence |
title_sort | development of a new patient-reported medication adherence instrument: concerns influencing medication adherence |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437415/ https://www.ncbi.nlm.nih.gov/pubmed/34526767 http://dx.doi.org/10.2147/PPA.S318030 |
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