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Beneficial autoimmunity links primary biliary cholangitis to the avoidance of cholangiocarcinoma
It has been an open conundrum why primary sclerosing cholangitis (PSC) is a major risk factor for developing cholangiocarcinoma (CAA), while primary biliary cholangitis (PBC) is not. In mouse models of PSC and PBC, it turned out that the latter condition, an autoimmune disease affecting the bile duc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437477/ https://www.ncbi.nlm.nih.gov/pubmed/34527429 http://dx.doi.org/10.1080/2162402X.2021.1968595 |
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author | Pol, Jonathan G. Paillet, Juliette Plantureux, Céleste Kroemer, Guido |
author_facet | Pol, Jonathan G. Paillet, Juliette Plantureux, Céleste Kroemer, Guido |
author_sort | Pol, Jonathan G. |
collection | PubMed |
description | It has been an open conundrum why primary sclerosing cholangitis (PSC) is a major risk factor for developing cholangiocarcinoma (CAA), while primary biliary cholangitis (PBC) is not. In mouse models of PSC and PBC, it turned out that the latter condition, an autoimmune disease affecting the bile ducts, reduces transgene-induced cholangiocarcinogenesis, as well as the progression of subcutaneously implanted CCA. This CCA-delaying effect is lost upon depletion of T lymphocytes and involves tumor infiltration by T cell clonotypes that are also found in PBC lesions. Hence, organ-specific autoimmunity may improve immunosurveillance. |
format | Online Article Text |
id | pubmed-8437477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-84374772021-09-14 Beneficial autoimmunity links primary biliary cholangitis to the avoidance of cholangiocarcinoma Pol, Jonathan G. Paillet, Juliette Plantureux, Céleste Kroemer, Guido Oncoimmunology Author’s View It has been an open conundrum why primary sclerosing cholangitis (PSC) is a major risk factor for developing cholangiocarcinoma (CAA), while primary biliary cholangitis (PBC) is not. In mouse models of PSC and PBC, it turned out that the latter condition, an autoimmune disease affecting the bile ducts, reduces transgene-induced cholangiocarcinogenesis, as well as the progression of subcutaneously implanted CCA. This CCA-delaying effect is lost upon depletion of T lymphocytes and involves tumor infiltration by T cell clonotypes that are also found in PBC lesions. Hence, organ-specific autoimmunity may improve immunosurveillance. Taylor & Francis 2021-09-11 /pmc/articles/PMC8437477/ /pubmed/34527429 http://dx.doi.org/10.1080/2162402X.2021.1968595 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Author’s View Pol, Jonathan G. Paillet, Juliette Plantureux, Céleste Kroemer, Guido Beneficial autoimmunity links primary biliary cholangitis to the avoidance of cholangiocarcinoma |
title | Beneficial autoimmunity links primary biliary cholangitis to the avoidance of cholangiocarcinoma |
title_full | Beneficial autoimmunity links primary biliary cholangitis to the avoidance of cholangiocarcinoma |
title_fullStr | Beneficial autoimmunity links primary biliary cholangitis to the avoidance of cholangiocarcinoma |
title_full_unstemmed | Beneficial autoimmunity links primary biliary cholangitis to the avoidance of cholangiocarcinoma |
title_short | Beneficial autoimmunity links primary biliary cholangitis to the avoidance of cholangiocarcinoma |
title_sort | beneficial autoimmunity links primary biliary cholangitis to the avoidance of cholangiocarcinoma |
topic | Author’s View |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437477/ https://www.ncbi.nlm.nih.gov/pubmed/34527429 http://dx.doi.org/10.1080/2162402X.2021.1968595 |
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