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Redox-Dependent Effects in the Physiopathological Role of Bile Acids

Bile acids (BA) are recognized by their role in nutrient absorption. However, there is growing evidence that BA also have endocrine and metabolic functions. Besides, the steroidal-derived structure gives BA a toxic potential over the biological membrane. Thus, cholestatic disorders, characterized by...

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Autores principales: Orozco-Aguilar, Josué, Simon, Felipe, Cabello-Verrugio, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437588/
https://www.ncbi.nlm.nih.gov/pubmed/34527174
http://dx.doi.org/10.1155/2021/4847941
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author Orozco-Aguilar, Josué
Simon, Felipe
Cabello-Verrugio, Claudio
author_facet Orozco-Aguilar, Josué
Simon, Felipe
Cabello-Verrugio, Claudio
author_sort Orozco-Aguilar, Josué
collection PubMed
description Bile acids (BA) are recognized by their role in nutrient absorption. However, there is growing evidence that BA also have endocrine and metabolic functions. Besides, the steroidal-derived structure gives BA a toxic potential over the biological membrane. Thus, cholestatic disorders, characterized by elevated BA on the liver and serum, are a significant cause of liver transplant and extrahepatic complications, such as skeletal muscle, central nervous system (CNS), heart, and placenta. Further, the BA have an essential role in cellular damage, mediating processes such as membrane disruption, mitochondrial dysfunction, and the generation of reactive oxygen species (ROS) and oxidative stress. The purpose of this review is to describe the BA and their role on hepatic and extrahepatic complications in cholestatic diseases, focusing on the association between BA and the generation of oxidative stress that mediates tissue damage.
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spelling pubmed-84375882021-09-14 Redox-Dependent Effects in the Physiopathological Role of Bile Acids Orozco-Aguilar, Josué Simon, Felipe Cabello-Verrugio, Claudio Oxid Med Cell Longev Review Article Bile acids (BA) are recognized by their role in nutrient absorption. However, there is growing evidence that BA also have endocrine and metabolic functions. Besides, the steroidal-derived structure gives BA a toxic potential over the biological membrane. Thus, cholestatic disorders, characterized by elevated BA on the liver and serum, are a significant cause of liver transplant and extrahepatic complications, such as skeletal muscle, central nervous system (CNS), heart, and placenta. Further, the BA have an essential role in cellular damage, mediating processes such as membrane disruption, mitochondrial dysfunction, and the generation of reactive oxygen species (ROS) and oxidative stress. The purpose of this review is to describe the BA and their role on hepatic and extrahepatic complications in cholestatic diseases, focusing on the association between BA and the generation of oxidative stress that mediates tissue damage. Hindawi 2021-09-04 /pmc/articles/PMC8437588/ /pubmed/34527174 http://dx.doi.org/10.1155/2021/4847941 Text en Copyright © 2021 Josué Orozco-Aguilar et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Orozco-Aguilar, Josué
Simon, Felipe
Cabello-Verrugio, Claudio
Redox-Dependent Effects in the Physiopathological Role of Bile Acids
title Redox-Dependent Effects in the Physiopathological Role of Bile Acids
title_full Redox-Dependent Effects in the Physiopathological Role of Bile Acids
title_fullStr Redox-Dependent Effects in the Physiopathological Role of Bile Acids
title_full_unstemmed Redox-Dependent Effects in the Physiopathological Role of Bile Acids
title_short Redox-Dependent Effects in the Physiopathological Role of Bile Acids
title_sort redox-dependent effects in the physiopathological role of bile acids
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437588/
https://www.ncbi.nlm.nih.gov/pubmed/34527174
http://dx.doi.org/10.1155/2021/4847941
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