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Decentralized vitamin C & D dual biosensor chip: Toward personalized immune system support
Combating the ongoing COVID-19 pandemic has put the spotlight on nutritional support of the immune system through consumption of vitamins C and D. Accordingly, there are urgent demands for an effective on-the-spot multi-vitamin self-testing platform that monitors the levels of these immune-supportin...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437685/ https://www.ncbi.nlm.nih.gov/pubmed/34474278 http://dx.doi.org/10.1016/j.bios.2021.113590 |
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author | Ruiz-Valdepeñas Montiel, Víctor Sempionatto, Juliane R. Vargas, Eva Bailey, Eileen May, Jennifer Bulbarello, Andrea Düsterloh, André Matusheski, Nathan Wang, Joseph |
author_facet | Ruiz-Valdepeñas Montiel, Víctor Sempionatto, Juliane R. Vargas, Eva Bailey, Eileen May, Jennifer Bulbarello, Andrea Düsterloh, André Matusheski, Nathan Wang, Joseph |
author_sort | Ruiz-Valdepeñas Montiel, Víctor |
collection | PubMed |
description | Combating the ongoing COVID-19 pandemic has put the spotlight on nutritional support of the immune system through consumption of vitamins C and D. Accordingly, there are urgent demands for an effective on-the-spot multi-vitamin self-testing platform that monitors the levels of these immune-supporting micronutrients for guiding precision nutrition recommendations. Herein, we present a compact bioelectronic dual sensor chip aimed at frequent on-the-spot simultaneous monitoring of the salivary vitamin C and D dynamics. The new bioelectronic chip combines a new electrocatalytic vitamin C amperometric assay along with competitive vitamin D immunoassay on neighboring electrodes, to perform selective and cross-talk free detection of both vitamins in a 10-μL saliva sample within 25 min. The distinct vitamin C or D temporal profiles obtained for different individuals after vitamin supplementation indicate the potential of the new bioelectronic chip strategy for enhancing personalized nutrition towards guiding dietary interventions to meet individual nutrition needs and promote immune system health. |
format | Online Article Text |
id | pubmed-8437685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84376852021-09-14 Decentralized vitamin C & D dual biosensor chip: Toward personalized immune system support Ruiz-Valdepeñas Montiel, Víctor Sempionatto, Juliane R. Vargas, Eva Bailey, Eileen May, Jennifer Bulbarello, Andrea Düsterloh, André Matusheski, Nathan Wang, Joseph Biosens Bioelectron Article Combating the ongoing COVID-19 pandemic has put the spotlight on nutritional support of the immune system through consumption of vitamins C and D. Accordingly, there are urgent demands for an effective on-the-spot multi-vitamin self-testing platform that monitors the levels of these immune-supporting micronutrients for guiding precision nutrition recommendations. Herein, we present a compact bioelectronic dual sensor chip aimed at frequent on-the-spot simultaneous monitoring of the salivary vitamin C and D dynamics. The new bioelectronic chip combines a new electrocatalytic vitamin C amperometric assay along with competitive vitamin D immunoassay on neighboring electrodes, to perform selective and cross-talk free detection of both vitamins in a 10-μL saliva sample within 25 min. The distinct vitamin C or D temporal profiles obtained for different individuals after vitamin supplementation indicate the potential of the new bioelectronic chip strategy for enhancing personalized nutrition towards guiding dietary interventions to meet individual nutrition needs and promote immune system health. Elsevier B.V. 2021-12-15 2021-08-26 /pmc/articles/PMC8437685/ /pubmed/34474278 http://dx.doi.org/10.1016/j.bios.2021.113590 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Ruiz-Valdepeñas Montiel, Víctor Sempionatto, Juliane R. Vargas, Eva Bailey, Eileen May, Jennifer Bulbarello, Andrea Düsterloh, André Matusheski, Nathan Wang, Joseph Decentralized vitamin C & D dual biosensor chip: Toward personalized immune system support |
title | Decentralized vitamin C & D dual biosensor chip: Toward personalized immune system support |
title_full | Decentralized vitamin C & D dual biosensor chip: Toward personalized immune system support |
title_fullStr | Decentralized vitamin C & D dual biosensor chip: Toward personalized immune system support |
title_full_unstemmed | Decentralized vitamin C & D dual biosensor chip: Toward personalized immune system support |
title_short | Decentralized vitamin C & D dual biosensor chip: Toward personalized immune system support |
title_sort | decentralized vitamin c & d dual biosensor chip: toward personalized immune system support |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437685/ https://www.ncbi.nlm.nih.gov/pubmed/34474278 http://dx.doi.org/10.1016/j.bios.2021.113590 |
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