Persistence of virus-neutralizing antibodies in horses inoculated with two doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals

The antibody response in horses inoculated with 2 doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals (1 to 3 months) was evaluated with regard to the persistence of virus-neutralizing (VN) antibodies. The durations for which the geometric mean VN titers were maint...

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Autores principales: BANNAI, Hiroshi, KAMBAYASHI, Yoshinori, TSUJIMURA, Koji, NAGASHIMA, Tsuyoshi, TAKEBE, Naoya, TOMINARI, Masataka, NEMOTO, Manabu, OHTA, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Equine Science 2021
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437755/
https://www.ncbi.nlm.nih.gov/pubmed/34539211
http://dx.doi.org/10.1294/jes.32.99
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author BANNAI, Hiroshi
KAMBAYASHI, Yoshinori
TSUJIMURA, Koji
NAGASHIMA, Tsuyoshi
TAKEBE, Naoya
TOMINARI, Masataka
NEMOTO, Manabu
OHTA, Minoru
author_facet BANNAI, Hiroshi
KAMBAYASHI, Yoshinori
TSUJIMURA, Koji
NAGASHIMA, Tsuyoshi
TAKEBE, Naoya
TOMINARI, Masataka
NEMOTO, Manabu
OHTA, Minoru
author_sort BANNAI, Hiroshi
collection PubMed
description The antibody response in horses inoculated with 2 doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals (1 to 3 months) was evaluated with regard to the persistence of virus-neutralizing (VN) antibodies. The durations for which the geometric mean VN titers were maintained significantly higher than those before the first vaccination (P<0.05) were up to 5 months in horses that received the vaccination with a 1-month interval (n=17) and 7 months for those that received it with a 2-month (n=17) or 3-month interval (n=14 or 17). The vaccination program with the 2-month interval was the most effective in maintaining VN antibodies for a long duration with the smallest gap of antibody decline between the first and second vaccinations.
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spelling pubmed-84377552021-09-17 Persistence of virus-neutralizing antibodies in horses inoculated with two doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals BANNAI, Hiroshi KAMBAYASHI, Yoshinori TSUJIMURA, Koji NAGASHIMA, Tsuyoshi TAKEBE, Naoya TOMINARI, Masataka NEMOTO, Manabu OHTA, Minoru J Equine Sci Note The antibody response in horses inoculated with 2 doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals (1 to 3 months) was evaluated with regard to the persistence of virus-neutralizing (VN) antibodies. The durations for which the geometric mean VN titers were maintained significantly higher than those before the first vaccination (P<0.05) were up to 5 months in horses that received the vaccination with a 1-month interval (n=17) and 7 months for those that received it with a 2-month (n=17) or 3-month interval (n=14 or 17). The vaccination program with the 2-month interval was the most effective in maintaining VN antibodies for a long duration with the smallest gap of antibody decline between the first and second vaccinations. The Japanese Society of Equine Science 2021-09-06 2021-09 /pmc/articles/PMC8437755/ /pubmed/34539211 http://dx.doi.org/10.1294/jes.32.99 Text en ©2021 The Japanese Society of Equine Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Note
BANNAI, Hiroshi
KAMBAYASHI, Yoshinori
TSUJIMURA, Koji
NAGASHIMA, Tsuyoshi
TAKEBE, Naoya
TOMINARI, Masataka
NEMOTO, Manabu
OHTA, Minoru
Persistence of virus-neutralizing antibodies in horses inoculated with two doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals
title Persistence of virus-neutralizing antibodies in horses inoculated with two doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals
title_full Persistence of virus-neutralizing antibodies in horses inoculated with two doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals
title_fullStr Persistence of virus-neutralizing antibodies in horses inoculated with two doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals
title_full_unstemmed Persistence of virus-neutralizing antibodies in horses inoculated with two doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals
title_short Persistence of virus-neutralizing antibodies in horses inoculated with two doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals
title_sort persistence of virus-neutralizing antibodies in horses inoculated with two doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals
topic Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437755/
https://www.ncbi.nlm.nih.gov/pubmed/34539211
http://dx.doi.org/10.1294/jes.32.99
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