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ABO blood group association and COVID-19. COVID-19 susceptibility and severity: a review
INTRODUCTION: The SARS-CoV-2 pandemic has been affecting the health and economic, as well as social, life of the entire globe since the end of 2019. The virus causes COVID-19, with a wide range of symptoms among the infected individuals, from asymptomatic infection to mortality. This, along with a h...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Hematologia e Hemoterapia
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437766/ https://www.ncbi.nlm.nih.gov/pubmed/34541459 http://dx.doi.org/10.1016/j.htct.2021.07.006 |
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author | Shibeeb, Sapha Khan, Aisha |
author_facet | Shibeeb, Sapha Khan, Aisha |
author_sort | Shibeeb, Sapha |
collection | PubMed |
description | INTRODUCTION: The SARS-CoV-2 pandemic has been affecting the health and economic, as well as social, life of the entire globe since the end of 2019. The virus causes COVID-19, with a wide range of symptoms among the infected individuals, from asymptomatic infection to mortality. This, along with a high infection rate, prompted efforts to investigate the potential mechanisms of the different clinical manifestations caused by SARS-CoV-2 among the infected populations. HYPOTHESIS: One of the possible mechanisms that has been reported is the ABO blood system polymorphism. Indeed, one of the major proposed mechanisms is the presence of naturally occurring anti-A antibodies in individuals of groups O and B, which could be partially protective against SARS-CoV-2 virions. OBJECTIVE AND METHOD: This article aimed to review the published data on the potential effect of the ABO blood group system on the susceptibility to COVID-19 and the disease progression and outcomes. RESULTS: The reviewed data suggest that individuals of blood group A are at a higher risk of infection with SARS-CoV-2 and may develop severe COVID-19 outcomes, whereas blood group O is considered protective against the infection, to some extent. However, some of the available studies seem to have been influenced by unaccounted confounders and biases. CONCLUSION: Therefore, further appropriately controlled studies are warranted to fully investigate the possible association between the ABO blood groups and COVID-19 susceptibility and severity. |
format | Online Article Text |
id | pubmed-8437766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Sociedade Brasileira de Hematologia e Hemoterapia |
record_format | MEDLINE/PubMed |
spelling | pubmed-84377662021-09-14 ABO blood group association and COVID-19. COVID-19 susceptibility and severity: a review Shibeeb, Sapha Khan, Aisha Hematol Transfus Cell Ther Review Article INTRODUCTION: The SARS-CoV-2 pandemic has been affecting the health and economic, as well as social, life of the entire globe since the end of 2019. The virus causes COVID-19, with a wide range of symptoms among the infected individuals, from asymptomatic infection to mortality. This, along with a high infection rate, prompted efforts to investigate the potential mechanisms of the different clinical manifestations caused by SARS-CoV-2 among the infected populations. HYPOTHESIS: One of the possible mechanisms that has been reported is the ABO blood system polymorphism. Indeed, one of the major proposed mechanisms is the presence of naturally occurring anti-A antibodies in individuals of groups O and B, which could be partially protective against SARS-CoV-2 virions. OBJECTIVE AND METHOD: This article aimed to review the published data on the potential effect of the ABO blood group system on the susceptibility to COVID-19 and the disease progression and outcomes. RESULTS: The reviewed data suggest that individuals of blood group A are at a higher risk of infection with SARS-CoV-2 and may develop severe COVID-19 outcomes, whereas blood group O is considered protective against the infection, to some extent. However, some of the available studies seem to have been influenced by unaccounted confounders and biases. CONCLUSION: Therefore, further appropriately controlled studies are warranted to fully investigate the possible association between the ABO blood groups and COVID-19 susceptibility and severity. Sociedade Brasileira de Hematologia e Hemoterapia 2022 2021-09-14 /pmc/articles/PMC8437766/ /pubmed/34541459 http://dx.doi.org/10.1016/j.htct.2021.07.006 Text en © 2021 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Shibeeb, Sapha Khan, Aisha ABO blood group association and COVID-19. COVID-19 susceptibility and severity: a review |
title | ABO blood group association and COVID-19. COVID-19 susceptibility and severity: a review |
title_full | ABO blood group association and COVID-19. COVID-19 susceptibility and severity: a review |
title_fullStr | ABO blood group association and COVID-19. COVID-19 susceptibility and severity: a review |
title_full_unstemmed | ABO blood group association and COVID-19. COVID-19 susceptibility and severity: a review |
title_short | ABO blood group association and COVID-19. COVID-19 susceptibility and severity: a review |
title_sort | abo blood group association and covid-19. covid-19 susceptibility and severity: a review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437766/ https://www.ncbi.nlm.nih.gov/pubmed/34541459 http://dx.doi.org/10.1016/j.htct.2021.07.006 |
work_keys_str_mv | AT shibeebsapha abobloodgroupassociationandcovid19covid19susceptibilityandseverityareview AT khanaisha abobloodgroupassociationandcovid19covid19susceptibilityandseverityareview |