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Landscape of functional interactions of human processive ribonucleases revealed by high-throughput siRNA screenings
Processive exoribonucleases are executors of RNA decay. In humans, their physical but not functional interactions were thoughtfully investigated. Here we have screened cells deficient in DIS3, XRN2, EXOSC10, DIS3L, and DIS3L2 with a custom siRNA library and determined their genetic interactions (GIs...
Autores principales: | Hojka-Osinska, Anna, Chlebowski, Aleksander, Grochowska, Joanna, Owczarek, Ewelina P., Affek, Kamila, Kłosowska-Kosicka, Kamila, Szczesny, Roman J., Dziembowski, Andrzej |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437785/ https://www.ncbi.nlm.nih.gov/pubmed/34541468 http://dx.doi.org/10.1016/j.isci.2021.103036 |
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