Hypoxia regulates overall mRNA homeostasis by inducing Met(1)-linked linear ubiquitination of AGO2 in cancer cells

Hypoxia is the most prominent feature in human solid tumors and induces activation of hypoxia-inducible factors and their downstream genes to promote cancer progression. However, whether and how hypoxia regulates overall mRNA homeostasis is unclear. Here we show that hypoxia inhibits global-mRNA dec...

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Detalles Bibliográficos
Autores principales: Zhang, Hailong, Zhao, Xian, Guo, Yanmin, Chen, Ran, He, Jianfeng, Li, Lian, Qiang, Zhe, Yang, Qianqian, Liu, Xiaojia, Huang, Caihu, Lu, Runhui, Fang, Jiayu, Cao, Yingting, Huang, Jiayi, Wang, Yanli, Huang, Jian, Chen, Guo-Qiang, Cheng, Jinke, Yu, Jianxiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438024/
https://www.ncbi.nlm.nih.gov/pubmed/34518544
http://dx.doi.org/10.1038/s41467-021-25739-5

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