A microfluidic approach to rescue ALS motor neuron degeneration using rapamycin

TAR DNA-binding protein-43 (TDP-43) is known to accumulate in ubiquitinated inclusions of amyotrophic lateral sclerosis affected motor neurons, resulting in motor neuron degeneration, loss of motor functions, and eventually death. Rapamycin, an mTOR inhibitor and a commonly used immunosuppressive dr...

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Detalles Bibliográficos
Autores principales: Chennampally, Phaneendra, Sayed-Zahid, Ambreen, Soundararajan, Prabakaran, Sharp, Jocelyn, Cox, Gregory A., Collins, Scott D., Smith, Rosemary L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438029/
https://www.ncbi.nlm.nih.gov/pubmed/34518579
http://dx.doi.org/10.1038/s41598-021-97405-1

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