Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression

Chromosomal instability (CIN) and epigenetic alterations have been implicated in tumor progression and metastasis; yet how these two hallmarks of cancer are related remains poorly understood. By integrating genetic, epigenetic, and functional analyses at the single cell level, we show that progressi...

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Detalles Bibliográficos
Autores principales: Bakhoum, Mathieu F., Francis, Jasmine H., Agustinus, Albert, Earlie, Ethan M., Di Bona, Melody, Abramson, David H., Duran, Mercedes, Masilionis, Ignas, Molina, Elsa, Shoushtari, Alexander N., Goldbaum, Michael H., Mischel, Paul S., Bakhoum, Samuel F., Laughney, Ashley M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438051/
https://www.ncbi.nlm.nih.gov/pubmed/34518527
http://dx.doi.org/10.1038/s41467-021-25529-z

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