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The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson’s disease

Dopaminergic (DA) cell replacement therapies are a promising experimental treatment for Parkinson’s disease (PD) and a number of different types of DA cell-based therapies have already been trialled in patients. To date, the most successful have been allotransplants of foetal ventral midbrain but ev...

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Detalles Bibliográficos
Autores principales: Qarin, Shamma, Howlett, Sarah K., Jones, Joanne L., Barker, Roger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438115/
https://www.ncbi.nlm.nih.gov/pubmed/34552761
http://dx.doi.org/10.1042/NS20200083
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author Qarin, Shamma
Howlett, Sarah K.
Jones, Joanne L.
Barker, Roger A.
author_facet Qarin, Shamma
Howlett, Sarah K.
Jones, Joanne L.
Barker, Roger A.
author_sort Qarin, Shamma
collection PubMed
description Dopaminergic (DA) cell replacement therapies are a promising experimental treatment for Parkinson’s disease (PD) and a number of different types of DA cell-based therapies have already been trialled in patients. To date, the most successful have been allotransplants of foetal ventral midbrain but even then, the results have been inconsistent. This coupled to the ethical and logistical problems with using this tissue has meant that an alternative cell source has been sought of which human pluripotent stem cells (hPSCs) sources have proven very attractive. Robust protocols for making mesencephalic DA (mesDA) progenitor cells from hPSCs now exist and the first in-human clinical trials have or are about to start. However, while their safety and efficacy are well understood, relatively little is known about their immunogenicity and in this review, we briefly summarise this with reference mainly to the limited literature on human foetal DA cells.
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spelling pubmed-84381152021-09-21 The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson’s disease Qarin, Shamma Howlett, Sarah K. Jones, Joanne L. Barker, Roger A. Neuronal Signal Immunology & Inflammation Dopaminergic (DA) cell replacement therapies are a promising experimental treatment for Parkinson’s disease (PD) and a number of different types of DA cell-based therapies have already been trialled in patients. To date, the most successful have been allotransplants of foetal ventral midbrain but even then, the results have been inconsistent. This coupled to the ethical and logistical problems with using this tissue has meant that an alternative cell source has been sought of which human pluripotent stem cells (hPSCs) sources have proven very attractive. Robust protocols for making mesencephalic DA (mesDA) progenitor cells from hPSCs now exist and the first in-human clinical trials have or are about to start. However, while their safety and efficacy are well understood, relatively little is known about their immunogenicity and in this review, we briefly summarise this with reference mainly to the limited literature on human foetal DA cells. Portland Press Ltd. 2021-09-13 /pmc/articles/PMC8438115/ /pubmed/34552761 http://dx.doi.org/10.1042/NS20200083 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . Open access for this article was enabled by the participation of University of Cambridge in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC.
spellingShingle Immunology & Inflammation
Qarin, Shamma
Howlett, Sarah K.
Jones, Joanne L.
Barker, Roger A.
The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson’s disease
title The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson’s disease
title_full The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson’s disease
title_fullStr The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson’s disease
title_full_unstemmed The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson’s disease
title_short The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson’s disease
title_sort immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in parkinson’s disease
topic Immunology & Inflammation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438115/
https://www.ncbi.nlm.nih.gov/pubmed/34552761
http://dx.doi.org/10.1042/NS20200083
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