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Update on the Role of the Endothelial Glycocalyx in Angiogenesis and Vascular Inflammation
The endothelial glycocalyx is a negatively charged, carbohydrate-rich structure that arises from the luminal surface of the vascular endothelium and is comprised of proteoglycans, glycoproteins, and glycolipids. The glycocalyx, which sits at the interface between the endothelium and the blood, is in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438194/ https://www.ncbi.nlm.nih.gov/pubmed/34532323 http://dx.doi.org/10.3389/fcell.2021.734276 |
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author | Hu, Zhengping Cano, Issahy D’Amore, Patricia A. |
author_facet | Hu, Zhengping Cano, Issahy D’Amore, Patricia A. |
author_sort | Hu, Zhengping |
collection | PubMed |
description | The endothelial glycocalyx is a negatively charged, carbohydrate-rich structure that arises from the luminal surface of the vascular endothelium and is comprised of proteoglycans, glycoproteins, and glycolipids. The glycocalyx, which sits at the interface between the endothelium and the blood, is involved in a wide array of physiological and pathophysiological processes, including as a mechanotransducer and as a regulator of inflammation. Most recently, components of the glycocalyx have been shown to play a key role in controlling angiogenesis. In this review, we briefly summarize the structure and function of the endothelial glycocalyx. We focus on its role and functions in vascular inflammation and angiogenesis and discuss the important unanswered questions in this field. |
format | Online Article Text |
id | pubmed-8438194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84381942021-09-15 Update on the Role of the Endothelial Glycocalyx in Angiogenesis and Vascular Inflammation Hu, Zhengping Cano, Issahy D’Amore, Patricia A. Front Cell Dev Biol Cell and Developmental Biology The endothelial glycocalyx is a negatively charged, carbohydrate-rich structure that arises from the luminal surface of the vascular endothelium and is comprised of proteoglycans, glycoproteins, and glycolipids. The glycocalyx, which sits at the interface between the endothelium and the blood, is involved in a wide array of physiological and pathophysiological processes, including as a mechanotransducer and as a regulator of inflammation. Most recently, components of the glycocalyx have been shown to play a key role in controlling angiogenesis. In this review, we briefly summarize the structure and function of the endothelial glycocalyx. We focus on its role and functions in vascular inflammation and angiogenesis and discuss the important unanswered questions in this field. Frontiers Media S.A. 2021-08-31 /pmc/articles/PMC8438194/ /pubmed/34532323 http://dx.doi.org/10.3389/fcell.2021.734276 Text en Copyright © 2021 Hu, Cano and D’Amore. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Hu, Zhengping Cano, Issahy D’Amore, Patricia A. Update on the Role of the Endothelial Glycocalyx in Angiogenesis and Vascular Inflammation |
title | Update on the Role of the Endothelial Glycocalyx in Angiogenesis and Vascular Inflammation |
title_full | Update on the Role of the Endothelial Glycocalyx in Angiogenesis and Vascular Inflammation |
title_fullStr | Update on the Role of the Endothelial Glycocalyx in Angiogenesis and Vascular Inflammation |
title_full_unstemmed | Update on the Role of the Endothelial Glycocalyx in Angiogenesis and Vascular Inflammation |
title_short | Update on the Role of the Endothelial Glycocalyx in Angiogenesis and Vascular Inflammation |
title_sort | update on the role of the endothelial glycocalyx in angiogenesis and vascular inflammation |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438194/ https://www.ncbi.nlm.nih.gov/pubmed/34532323 http://dx.doi.org/10.3389/fcell.2021.734276 |
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