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The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments

At present, percutaneous coronary intervention (PCI) is the most effective treatment of coronary artery stenosis. However, in case post-dilation of the stent is needed, the tip of the commonly used post-dilation balloon catheter cannot always pass through the stent smoothly, especially when it is si...

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Detalles Bibliográficos
Autores principales: Qi, Lin, Zhu, Wenbo, Qian, Wei, Xu, Lisheng, He, Ying, Zhao, Feihu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438231/
https://www.ncbi.nlm.nih.gov/pubmed/34531765
http://dx.doi.org/10.3389/fphys.2021.734565
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author Qi, Lin
Zhu, Wenbo
Qian, Wei
Xu, Lisheng
He, Ying
Zhao, Feihu
author_facet Qi, Lin
Zhu, Wenbo
Qian, Wei
Xu, Lisheng
He, Ying
Zhao, Feihu
author_sort Qi, Lin
collection PubMed
description At present, percutaneous coronary intervention (PCI) is the most effective treatment of coronary artery stenosis. However, in case post-dilation of the stent is needed, the tip of the commonly used post-dilation balloon catheter cannot always pass through the stent smoothly, especially when it is situated in the curved part of the vessel. To improve the performance of traditional post-dilation balloon catheter, a preliminary design of a novel catheter with a spherical-tip is proposed. Since the performance of this spherical-tip catheter is still unclear, in this study, finite element analysis (FEA) and experimental validation of blood vessel with different curvature radii were performed to test and evaluate the performance of the spherical-tip catheter design. The comparative results between the two types of catheters demonstrate that in the simulated post-dilation process, the spherical-tip catheter is easier to pass through the stent placed in the curved vessel without the deformation of the stent strut, and can theoretically reduce the operation time and improve the safety of the operation. Furthermore, the strong consistency between simulation and experiment indicates that the finite element (FE) model can be a helpful tool for future optimization and evaluation of novel catheters, so as to save time and budget in product development and reduce/replace animal studies.
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spelling pubmed-84382312021-09-15 The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments Qi, Lin Zhu, Wenbo Qian, Wei Xu, Lisheng He, Ying Zhao, Feihu Front Physiol Physiology At present, percutaneous coronary intervention (PCI) is the most effective treatment of coronary artery stenosis. However, in case post-dilation of the stent is needed, the tip of the commonly used post-dilation balloon catheter cannot always pass through the stent smoothly, especially when it is situated in the curved part of the vessel. To improve the performance of traditional post-dilation balloon catheter, a preliminary design of a novel catheter with a spherical-tip is proposed. Since the performance of this spherical-tip catheter is still unclear, in this study, finite element analysis (FEA) and experimental validation of blood vessel with different curvature radii were performed to test and evaluate the performance of the spherical-tip catheter design. The comparative results between the two types of catheters demonstrate that in the simulated post-dilation process, the spherical-tip catheter is easier to pass through the stent placed in the curved vessel without the deformation of the stent strut, and can theoretically reduce the operation time and improve the safety of the operation. Furthermore, the strong consistency between simulation and experiment indicates that the finite element (FE) model can be a helpful tool for future optimization and evaluation of novel catheters, so as to save time and budget in product development and reduce/replace animal studies. Frontiers Media S.A. 2021-08-31 /pmc/articles/PMC8438231/ /pubmed/34531765 http://dx.doi.org/10.3389/fphys.2021.734565 Text en Copyright © 2021 Qi, Zhu, Qian, Xu, He and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Qi, Lin
Zhu, Wenbo
Qian, Wei
Xu, Lisheng
He, Ying
Zhao, Feihu
The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments
title The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments
title_full The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments
title_fullStr The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments
title_full_unstemmed The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments
title_short The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments
title_sort performance of a spherical-tip catheter for stent post-dilation: finite element analysis and experiments
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438231/
https://www.ncbi.nlm.nih.gov/pubmed/34531765
http://dx.doi.org/10.3389/fphys.2021.734565
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