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Prognostic implications of histological organ involvement in retroperitoneal sarcoma

BACKGROUND: The prognostic significance of histological organ involvement by retroperitoneal sarcoma subtype is unknown. The present study aimed to describe organ involvement across the subtypes, and the implications for survival. METHODS: Patients undergoing surgery for primary retroperitoneal sarc...

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Autores principales: Tyler, R, Lee, M, Ierodiakonou, V, Hodson, J, Taniere, P, Almond, M, Ford, S, Desai, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438256/
https://www.ncbi.nlm.nih.gov/pubmed/34518873
http://dx.doi.org/10.1093/bjsopen/zrab080
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author Tyler, R
Lee, M
Ierodiakonou, V
Hodson, J
Taniere, P
Almond, M
Ford, S
Desai, A
author_facet Tyler, R
Lee, M
Ierodiakonou, V
Hodson, J
Taniere, P
Almond, M
Ford, S
Desai, A
author_sort Tyler, R
collection PubMed
description BACKGROUND: The prognostic significance of histological organ involvement by retroperitoneal sarcoma subtype is unknown. The present study aimed to describe organ involvement across the subtypes, and the implications for survival. METHODS: Patients undergoing surgery for primary retroperitoneal sarcoma at the Queen Elizabeth Hospital, Birmingham from April 2005 to September 2018 were identified retrospectively. Histological organ involvement was classed as pushing, infiltrative or neither. Univariable and multivariable Cox regression models were produced to analyse the association between histological organ involvement and both overall (OS) and recurrence-free (RFS) survival for the cohort as a whole, and by histological subtype. RESULTS: Data were available for a total of 197 patients, of whom 171 (86.8 per cent) had at least one organ resected. Infiltrative organ behaviour was seen in 37 patients (18.8 per cent), and pushing behaviour in 67 (34.0 per cent). For the cohort as a whole, infiltration (hazard ratio (HR) 4.32, 95 per cent c.i. 2.35 to 7.93; P < 0.001), but not pushing (HR 1.62, 0.90 to 2.92; P = 0.106), was associated with significantly shorter OS, in comparisons with a group with neither of these behaviours. However, this effect was found to differ significantly by histological subtype (P = 0.009). For patients with dedifferentiated liposarcoma, there was no significant association between tumour behaviour and either OS (P = 0.508) or RFS (P = 0.313). However, in leiomyosarcoma, infiltrative behaviour was associated with shorter OS (P = 0.002), and both infiltrative (P < 0.001) and pushing (P = 0.010) behaviours were associated with shorter RFS, compared with tumours with neither behaviour. Multivariable analyses of both OS and RFS returned similar results. CONCLUSION: The prognostic implications of organ involvement in retroperitoneal sarcoma vary by histological subtype.
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spelling pubmed-84382562021-09-15 Prognostic implications of histological organ involvement in retroperitoneal sarcoma Tyler, R Lee, M Ierodiakonou, V Hodson, J Taniere, P Almond, M Ford, S Desai, A BJS Open Original Article BACKGROUND: The prognostic significance of histological organ involvement by retroperitoneal sarcoma subtype is unknown. The present study aimed to describe organ involvement across the subtypes, and the implications for survival. METHODS: Patients undergoing surgery for primary retroperitoneal sarcoma at the Queen Elizabeth Hospital, Birmingham from April 2005 to September 2018 were identified retrospectively. Histological organ involvement was classed as pushing, infiltrative or neither. Univariable and multivariable Cox regression models were produced to analyse the association between histological organ involvement and both overall (OS) and recurrence-free (RFS) survival for the cohort as a whole, and by histological subtype. RESULTS: Data were available for a total of 197 patients, of whom 171 (86.8 per cent) had at least one organ resected. Infiltrative organ behaviour was seen in 37 patients (18.8 per cent), and pushing behaviour in 67 (34.0 per cent). For the cohort as a whole, infiltration (hazard ratio (HR) 4.32, 95 per cent c.i. 2.35 to 7.93; P < 0.001), but not pushing (HR 1.62, 0.90 to 2.92; P = 0.106), was associated with significantly shorter OS, in comparisons with a group with neither of these behaviours. However, this effect was found to differ significantly by histological subtype (P = 0.009). For patients with dedifferentiated liposarcoma, there was no significant association between tumour behaviour and either OS (P = 0.508) or RFS (P = 0.313). However, in leiomyosarcoma, infiltrative behaviour was associated with shorter OS (P = 0.002), and both infiltrative (P < 0.001) and pushing (P = 0.010) behaviours were associated with shorter RFS, compared with tumours with neither behaviour. Multivariable analyses of both OS and RFS returned similar results. CONCLUSION: The prognostic implications of organ involvement in retroperitoneal sarcoma vary by histological subtype. Oxford University Press 2021-09-14 /pmc/articles/PMC8438256/ /pubmed/34518873 http://dx.doi.org/10.1093/bjsopen/zrab080 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of BJS Society Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Article
Tyler, R
Lee, M
Ierodiakonou, V
Hodson, J
Taniere, P
Almond, M
Ford, S
Desai, A
Prognostic implications of histological organ involvement in retroperitoneal sarcoma
title Prognostic implications of histological organ involvement in retroperitoneal sarcoma
title_full Prognostic implications of histological organ involvement in retroperitoneal sarcoma
title_fullStr Prognostic implications of histological organ involvement in retroperitoneal sarcoma
title_full_unstemmed Prognostic implications of histological organ involvement in retroperitoneal sarcoma
title_short Prognostic implications of histological organ involvement in retroperitoneal sarcoma
title_sort prognostic implications of histological organ involvement in retroperitoneal sarcoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438256/
https://www.ncbi.nlm.nih.gov/pubmed/34518873
http://dx.doi.org/10.1093/bjsopen/zrab080
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