Molecular epidemiology of a familial cluster of SARS-CoV-2 infection during lockdown period in Sant Kabir Nagar, Uttar Pradesh, India

We report a familial cluster of 24 individuals infected with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The index case had a travel history and spent 24 days in the house before being tested and was asymptomatic. Physical overcrowding in the house provided a favourable environment...

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Autores principales: Zaman, Kamran, Shankar, Prem, Yadav, Pragya D., Nyayanit, Dimpal A., Behera, Sthita Pragnya, Bhardwaj, Pooja, Shete, Anita, Majumdar, Triparna, Yadav, Rajaram, Patil, Savita, Deval, Hirawati, Dwivedi, Gaurav Raj, Pandey, Ashok K., Singh, Rajeev, Misra, Brij R., Kumar, Niraj, Kumar, Kaushik, Yadav, Priyanka, Yadav, Girijesh Kumar, Kumar, Manoj, Sah, Kamlesh Kumar, Singh, Ravi Shankar, Kumar, Sanjeev, Kavathekar, Asif, Kumar, Vijay, Kant, Rajni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Short Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438426/
http://dx.doi.org/10.1017/S0950268821001989
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author Zaman, Kamran
Shankar, Prem
Yadav, Pragya D.
Nyayanit, Dimpal A.
Behera, Sthita Pragnya
Bhardwaj, Pooja
Shete, Anita
Majumdar, Triparna
Yadav, Rajaram
Patil, Savita
Deval, Hirawati
Dwivedi, Gaurav Raj
Pandey, Ashok K.
Singh, Rajeev
Misra, Brij R.
Kumar, Niraj
Kumar, Kaushik
Yadav, Priyanka
Yadav, Girijesh Kumar
Kumar, Manoj
Sah, Kamlesh Kumar
Singh, Ravi Shankar
Kumar, Sanjeev
Kavathekar, Asif
Kumar, Vijay
Kant, Rajni
author_facet Zaman, Kamran
Shankar, Prem
Yadav, Pragya D.
Nyayanit, Dimpal A.
Behera, Sthita Pragnya
Bhardwaj, Pooja
Shete, Anita
Majumdar, Triparna
Yadav, Rajaram
Patil, Savita
Deval, Hirawati
Dwivedi, Gaurav Raj
Pandey, Ashok K.
Singh, Rajeev
Misra, Brij R.
Kumar, Niraj
Kumar, Kaushik
Yadav, Priyanka
Yadav, Girijesh Kumar
Kumar, Manoj
Sah, Kamlesh Kumar
Singh, Ravi Shankar
Kumar, Sanjeev
Kavathekar, Asif
Kumar, Vijay
Kant, Rajni
author_sort Zaman, Kamran
collection PubMed
description We report a familial cluster of 24 individuals infected with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The index case had a travel history and spent 24 days in the house before being tested and was asymptomatic. Physical overcrowding in the house provided a favourable environment for intra-cluster infection transmission. Restriction of movement of family members due to countrywide lockdown limited the spread in community. Among the infected, only four individuals developed symptoms. The complete genome sequences of SARS-CoV-2 was retrieved using next-generation sequencing from eight clinical samples which demonstrated a 99.99% similarity with reference to Wuhan strain and the phylogenetic analysis demonstrated a distinct cluster, lying in the B.6.6 pangolin lineage.
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spelling pubmed-84384262021-09-14 Molecular epidemiology of a familial cluster of SARS-CoV-2 infection during lockdown period in Sant Kabir Nagar, Uttar Pradesh, India Zaman, Kamran Shankar, Prem Yadav, Pragya D. Nyayanit, Dimpal A. Behera, Sthita Pragnya Bhardwaj, Pooja Shete, Anita Majumdar, Triparna Yadav, Rajaram Patil, Savita Deval, Hirawati Dwivedi, Gaurav Raj Pandey, Ashok K. Singh, Rajeev Misra, Brij R. Kumar, Niraj Kumar, Kaushik Yadav, Priyanka Yadav, Girijesh Kumar Kumar, Manoj Sah, Kamlesh Kumar Singh, Ravi Shankar Kumar, Sanjeev Kavathekar, Asif Kumar, Vijay Kant, Rajni Epidemiol Infect Short Paper We report a familial cluster of 24 individuals infected with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The index case had a travel history and spent 24 days in the house before being tested and was asymptomatic. Physical overcrowding in the house provided a favourable environment for intra-cluster infection transmission. Restriction of movement of family members due to countrywide lockdown limited the spread in community. Among the infected, only four individuals developed symptoms. The complete genome sequences of SARS-CoV-2 was retrieved using next-generation sequencing from eight clinical samples which demonstrated a 99.99% similarity with reference to Wuhan strain and the phylogenetic analysis demonstrated a distinct cluster, lying in the B.6.6 pangolin lineage. Cambridge University Press 2021-08-25 /pmc/articles/PMC8438426/ http://dx.doi.org/10.1017/S0950268821001989 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
spellingShingle Short Paper
Zaman, Kamran
Shankar, Prem
Yadav, Pragya D.
Nyayanit, Dimpal A.
Behera, Sthita Pragnya
Bhardwaj, Pooja
Shete, Anita
Majumdar, Triparna
Yadav, Rajaram
Patil, Savita
Deval, Hirawati
Dwivedi, Gaurav Raj
Pandey, Ashok K.
Singh, Rajeev
Misra, Brij R.
Kumar, Niraj
Kumar, Kaushik
Yadav, Priyanka
Yadav, Girijesh Kumar
Kumar, Manoj
Sah, Kamlesh Kumar
Singh, Ravi Shankar
Kumar, Sanjeev
Kavathekar, Asif
Kumar, Vijay
Kant, Rajni
Molecular epidemiology of a familial cluster of SARS-CoV-2 infection during lockdown period in Sant Kabir Nagar, Uttar Pradesh, India
title Molecular epidemiology of a familial cluster of SARS-CoV-2 infection during lockdown period in Sant Kabir Nagar, Uttar Pradesh, India
title_full Molecular epidemiology of a familial cluster of SARS-CoV-2 infection during lockdown period in Sant Kabir Nagar, Uttar Pradesh, India
title_fullStr Molecular epidemiology of a familial cluster of SARS-CoV-2 infection during lockdown period in Sant Kabir Nagar, Uttar Pradesh, India
title_full_unstemmed Molecular epidemiology of a familial cluster of SARS-CoV-2 infection during lockdown period in Sant Kabir Nagar, Uttar Pradesh, India
title_short Molecular epidemiology of a familial cluster of SARS-CoV-2 infection during lockdown period in Sant Kabir Nagar, Uttar Pradesh, India
title_sort molecular epidemiology of a familial cluster of sars-cov-2 infection during lockdown period in sant kabir nagar, uttar pradesh, india
topic Short Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438426/
http://dx.doi.org/10.1017/S0950268821001989
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