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NRL(−/−) gene edited human embryonic stem cells generate rod‐deficient retinal organoids enriched in S‐cone‐like photoreceptors

Organoid cultures represent a unique tool to investigate the developmental complexity of tissues like the human retina. NRL is a transcription factor required for the specification and homeostasis of mammalian rod photoreceptors. In Nrl‐deficient mice, photoreceptor precursor cells do not differenti...

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Detalles Bibliográficos
Autores principales:	Cuevas, Elisa, Holder, Daniel L., Alshehri, Ashwak H., Tréguier, Julie, Lakowski, Jörn, Sowden, Jane C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2021
Materias:	Embryonic Stem Cells/Induced Pluripotent Stem Cells
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438615/ https://www.ncbi.nlm.nih.gov/pubmed/33400844 http://dx.doi.org/10.1002/stem.3325

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