Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine

Arg (R)-rich dipeptide repeat proteins (DPRs; poly(PR): Pro-Arg and poly(GR): Gly-Arg), encoded by a hexanucleotide expansion in the C9ORF72 gene, induce neurodegeneration in amyotrophic lateral sclerosis (ALS). Although R-rich DPRs undergo liquid–liquid phase separation (LLPS), which affects multip...

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Detalles Bibliográficos
Autores principales: Chen, Chen, Yamanaka, Yoshiaki, Ueda, Koji, Li, Peiying, Miyagi, Tamami, Harada, Yuichiro, Tezuka, Sayaka, Narumi, Satoshi, Sugimoto, Masahiro, Kuroda, Masahiko, Hayamizu, Yuhei, Kanekura, Kohsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438627/
https://www.ncbi.nlm.nih.gov/pubmed/34499080
http://dx.doi.org/10.1083/jcb.202103160

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