Can we trust in Sars-CoV-2 rapid antigen testing? Preliminary results from a paediatric cohort in the emergency department

BACKGROUND: Rapid identification of Covid-19 in the paediatric emergency department is critical; Antigen tests are fast but poorly investigated in children. AIMS: To investigate Sars-CoV-2 antigen rapid test in children. METHODS: We compare the performance of LumiraDx with molecular tests in a paedi...

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Autores principales: Denina, Marco, Giannone, Virginia, Curtoni, Antonio, Zanotto, Elisa, Garazzino, Silvia, Urbino, Antonio Francesco, Bondone, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438652/
https://www.ncbi.nlm.nih.gov/pubmed/34519927
http://dx.doi.org/10.1007/s11845-021-02776-z
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author Denina, Marco
Giannone, Virginia
Curtoni, Antonio
Zanotto, Elisa
Garazzino, Silvia
Urbino, Antonio Francesco
Bondone, Claudia
author_facet Denina, Marco
Giannone, Virginia
Curtoni, Antonio
Zanotto, Elisa
Garazzino, Silvia
Urbino, Antonio Francesco
Bondone, Claudia
author_sort Denina, Marco
collection PubMed
description BACKGROUND: Rapid identification of Covid-19 in the paediatric emergency department is critical; Antigen tests are fast but poorly investigated in children. AIMS: To investigate Sars-CoV-2 antigen rapid test in children. METHODS: We compare the performance of LumiraDx with molecular tests in a paediatric emergency department. RESULTS: A retrospective cohort of 191 patients with AT and PCR tests performed in the same episode was analysed; 16% resulted positive for Sars-CoV-2. Using the PCR test as the gold standard, we calculated antigen testing overall sensitivity of 94.1%, specificity of 91.9%, and NPV of 99.4%. Only one false-negative test was found. CONCLUSIONS: AT may be helpful in the initial screening of patients at PED.
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spelling pubmed-84386522021-09-14 Can we trust in Sars-CoV-2 rapid antigen testing? Preliminary results from a paediatric cohort in the emergency department Denina, Marco Giannone, Virginia Curtoni, Antonio Zanotto, Elisa Garazzino, Silvia Urbino, Antonio Francesco Bondone, Claudia Ir J Med Sci Brief Report BACKGROUND: Rapid identification of Covid-19 in the paediatric emergency department is critical; Antigen tests are fast but poorly investigated in children. AIMS: To investigate Sars-CoV-2 antigen rapid test in children. METHODS: We compare the performance of LumiraDx with molecular tests in a paediatric emergency department. RESULTS: A retrospective cohort of 191 patients with AT and PCR tests performed in the same episode was analysed; 16% resulted positive for Sars-CoV-2. Using the PCR test as the gold standard, we calculated antigen testing overall sensitivity of 94.1%, specificity of 91.9%, and NPV of 99.4%. Only one false-negative test was found. CONCLUSIONS: AT may be helpful in the initial screening of patients at PED. Springer International Publishing 2021-09-14 2022 /pmc/articles/PMC8438652/ /pubmed/34519927 http://dx.doi.org/10.1007/s11845-021-02776-z Text en © Royal Academy of Medicine in Ireland 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Report
Denina, Marco
Giannone, Virginia
Curtoni, Antonio
Zanotto, Elisa
Garazzino, Silvia
Urbino, Antonio Francesco
Bondone, Claudia
Can we trust in Sars-CoV-2 rapid antigen testing? Preliminary results from a paediatric cohort in the emergency department
title Can we trust in Sars-CoV-2 rapid antigen testing? Preliminary results from a paediatric cohort in the emergency department
title_full Can we trust in Sars-CoV-2 rapid antigen testing? Preliminary results from a paediatric cohort in the emergency department
title_fullStr Can we trust in Sars-CoV-2 rapid antigen testing? Preliminary results from a paediatric cohort in the emergency department
title_full_unstemmed Can we trust in Sars-CoV-2 rapid antigen testing? Preliminary results from a paediatric cohort in the emergency department
title_short Can we trust in Sars-CoV-2 rapid antigen testing? Preliminary results from a paediatric cohort in the emergency department
title_sort can we trust in sars-cov-2 rapid antigen testing? preliminary results from a paediatric cohort in the emergency department
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438652/
https://www.ncbi.nlm.nih.gov/pubmed/34519927
http://dx.doi.org/10.1007/s11845-021-02776-z
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