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Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments
INTRODUCTION: Large studies on cognitive profiles of patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD‐MCI) compared to Parkinson's disease (PD‐MCI) are rare. METHODS: Data from two multicenter cohort studies in AD and PD were merged using a unified base rate app...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438680/ https://www.ncbi.nlm.nih.gov/pubmed/34541284 http://dx.doi.org/10.1002/dad2.12223 |
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author | Ophey, Anja Wolfsgruber, Steffen Roeske, Sandra Polcher, Alexandra Spottke, Annika Frölich, Lutz Hüll, Michael Jessen, Frank Kornhuber, Johannes Maier, Wolfgang Peters, Oliver Ramirez, Alfredo Wiltfang, Jens Liepelt‐Scarfone, Inga Becker, Sara Berg, Daniela Schulz, Jörg B. Reetz, Kathrin Wojtala, Jennifer Kassubek, Jan Storch, Alexander Balzer‐Geldsetzer, Monika Hilker‐Roggendorf, Rüdiger Witt, Karsten Mollenhauer, Brit Trenkwalder, Claudia Wittchen, Hans‐Ullrich Riedel, Oliver Dodel, Richard Wagner, Michael Kalbe, Elke |
author_facet | Ophey, Anja Wolfsgruber, Steffen Roeske, Sandra Polcher, Alexandra Spottke, Annika Frölich, Lutz Hüll, Michael Jessen, Frank Kornhuber, Johannes Maier, Wolfgang Peters, Oliver Ramirez, Alfredo Wiltfang, Jens Liepelt‐Scarfone, Inga Becker, Sara Berg, Daniela Schulz, Jörg B. Reetz, Kathrin Wojtala, Jennifer Kassubek, Jan Storch, Alexander Balzer‐Geldsetzer, Monika Hilker‐Roggendorf, Rüdiger Witt, Karsten Mollenhauer, Brit Trenkwalder, Claudia Wittchen, Hans‐Ullrich Riedel, Oliver Dodel, Richard Wagner, Michael Kalbe, Elke |
author_sort | Ophey, Anja |
collection | PubMed |
description | INTRODUCTION: Large studies on cognitive profiles of patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD‐MCI) compared to Parkinson's disease (PD‐MCI) are rare. METHODS: Data from two multicenter cohort studies in AD and PD were merged using a unified base rate approach for the MCI diagnosis. Cognitive profiles were compared using scores derived from the Consortium to Establish a Registry for Alzheimer's Disease battery. RESULTS: Patients with AD‐MCI showed lower standardized scores on all memory test scores and a language test. Patients with PD‐MCI showed lower standardized scores in a set‐shifting measure as an executive task. A cross‐validated logistic regression with test scores as predictors was able to classify 72% of patients correctly to AD‐MCI versus PD‐MCI. DISCUSSION: The applied test battery successfully discriminated between AD‐MCI and PD‐MCI. Neuropsychological test batteries in clinical practice should always include a broad spectrum of cognitive domains to capture any cognitive changes. |
format | Online Article Text |
id | pubmed-8438680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84386802021-09-17 Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments Ophey, Anja Wolfsgruber, Steffen Roeske, Sandra Polcher, Alexandra Spottke, Annika Frölich, Lutz Hüll, Michael Jessen, Frank Kornhuber, Johannes Maier, Wolfgang Peters, Oliver Ramirez, Alfredo Wiltfang, Jens Liepelt‐Scarfone, Inga Becker, Sara Berg, Daniela Schulz, Jörg B. Reetz, Kathrin Wojtala, Jennifer Kassubek, Jan Storch, Alexander Balzer‐Geldsetzer, Monika Hilker‐Roggendorf, Rüdiger Witt, Karsten Mollenhauer, Brit Trenkwalder, Claudia Wittchen, Hans‐Ullrich Riedel, Oliver Dodel, Richard Wagner, Michael Kalbe, Elke Alzheimers Dement (Amst) Cognitive & Behavioral Assessment INTRODUCTION: Large studies on cognitive profiles of patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD‐MCI) compared to Parkinson's disease (PD‐MCI) are rare. METHODS: Data from two multicenter cohort studies in AD and PD were merged using a unified base rate approach for the MCI diagnosis. Cognitive profiles were compared using scores derived from the Consortium to Establish a Registry for Alzheimer's Disease battery. RESULTS: Patients with AD‐MCI showed lower standardized scores on all memory test scores and a language test. Patients with PD‐MCI showed lower standardized scores in a set‐shifting measure as an executive task. A cross‐validated logistic regression with test scores as predictors was able to classify 72% of patients correctly to AD‐MCI versus PD‐MCI. DISCUSSION: The applied test battery successfully discriminated between AD‐MCI and PD‐MCI. Neuropsychological test batteries in clinical practice should always include a broad spectrum of cognitive domains to capture any cognitive changes. John Wiley and Sons Inc. 2021-09-14 /pmc/articles/PMC8438680/ /pubmed/34541284 http://dx.doi.org/10.1002/dad2.12223 Text en © 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Cognitive & Behavioral Assessment Ophey, Anja Wolfsgruber, Steffen Roeske, Sandra Polcher, Alexandra Spottke, Annika Frölich, Lutz Hüll, Michael Jessen, Frank Kornhuber, Johannes Maier, Wolfgang Peters, Oliver Ramirez, Alfredo Wiltfang, Jens Liepelt‐Scarfone, Inga Becker, Sara Berg, Daniela Schulz, Jörg B. Reetz, Kathrin Wojtala, Jennifer Kassubek, Jan Storch, Alexander Balzer‐Geldsetzer, Monika Hilker‐Roggendorf, Rüdiger Witt, Karsten Mollenhauer, Brit Trenkwalder, Claudia Wittchen, Hans‐Ullrich Riedel, Oliver Dodel, Richard Wagner, Michael Kalbe, Elke Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments |
title | Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments |
title_full | Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments |
title_fullStr | Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments |
title_full_unstemmed | Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments |
title_short | Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments |
title_sort | cognitive profiles of patients with mild cognitive impairment due to alzheimer's versus parkinson's disease defined using a base rate approach: implications for neuropsychological assessments |
topic | Cognitive & Behavioral Assessment |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438680/ https://www.ncbi.nlm.nih.gov/pubmed/34541284 http://dx.doi.org/10.1002/dad2.12223 |
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